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Fast and accurate protein structure search with Foldseek
DC Field | Value | Language |
---|---|---|
dc.contributor.author | van Kempen, Michel | - |
dc.contributor.author | Kim, Stephanie S. | - |
dc.contributor.author | Tumescheit, Charlotte | - |
dc.contributor.author | Mirdita, Milot | - |
dc.contributor.author | Lee, Jeongjae | - |
dc.contributor.author | Gilchrist, Cameron L. M. | - |
dc.contributor.author | Soeding, Johannes | - |
dc.contributor.author | Steinegger, Martin | - |
dc.date.accessioned | 2024-05-16T01:25:37Z | - |
dc.date.available | 2024-05-16T01:25:37Z | - |
dc.date.created | 2023-06-02 | - |
dc.date.created | 2023-06-02 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | Nature Biotechnology, Vol.42 No.2, pp.243-246 | - |
dc.identifier.issn | 1087-0156 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202486 | - |
dc.description.abstract | As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a structural alphabet. Foldseek decreases computation times by four to five orders of magnitude with 86%, 88% and 133% of the sensitivities of Dali, TM-align and CE, respectively. Foldseek speeds up protein structural search by four to five orders of magnitude. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Fast and accurate protein structure search with Foldseek | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41587-023-01773-0 | - |
dc.citation.journaltitle | Nature Biotechnology | - |
dc.identifier.wosid | 000984647200001 | - |
dc.identifier.scopusid | 2-s2.0-85158125205 | - |
dc.citation.endpage | 246 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 243 | - |
dc.citation.volume | 42 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Steinegger, Martin | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STRUCTURE ALIGNMENT | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | ALGORITHM | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | SPACE | - |
dc.subject.keywordPlus | TIMES | - |
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