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Prognostic roles of leptin-signaling proteins, PD-L1, and tumor-infiltrating lymphocytes in surgically-resected biliary tract cancers
DC Field | Value | Language |
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dc.contributor.author | Byeon, Sun-ju | - |
dc.contributor.author | Chang, Mee Soo | - |
dc.contributor.author | Cho, Hwa Jin | - |
dc.contributor.author | Park, Jeong Hwan | - |
dc.contributor.author | Kim, Ki Hwan | - |
dc.contributor.author | Park, Jin Hyun | - |
dc.contributor.author | Choi, In Sil | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Han, Dong-Seok | - |
dc.contributor.author | Ahn, Hye Seong | - |
dc.contributor.author | Heo, Seung Chul | - |
dc.date.accessioned | 2024-05-16T01:30:22Z | - |
dc.date.available | 2024-05-16T01:30:22Z | - |
dc.date.created | 2023-05-04 | - |
dc.date.created | 2023-05-04 | - |
dc.date.created | 2023-05-04 | - |
dc.date.created | 2023-05-04 | - |
dc.date.issued | 2023-03 | - |
dc.identifier.citation | Journal of Surgical Oncology, Vol.127 No.4, pp.587-597 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202595 | - |
dc.description.abstract | Background Biliary tract cancers are rare, with a poor patient prognosis. Leptin and programmed death-ligand 1 (PD-L1) influence CD8(+) and forkhead box P3 (FOXP3)(+) lymphocytes, and thus, cancer cell growth. We aimed to define the prognostic implications of these variables and the clinicopathological features of biliary tract cancers. Methods Immunohistochemistry for leptin signaling-related proteins (leptin, leptin receptor, pSTAT3, extracellular-regulated kinase, mammalian target of rapamycin), PD-L1, CD8, and FOXP3 and in situ hybridization for Epstein-Barr virus-encoded small RNAs were performed in 147 cases of surgically-resected biliary tract cancers. Results Immune cell PD-L1-positivity, tumor size < 3 cm, adjuvant chemotherapy, no recurrence, and early-stage tumors were correlated with better 5-year survival in the tumoral PD-L1((-)) and leptin((-)) subgroups, and extrahepatic cholangiocarcinoma through multivariate analysis (all p < 0.05). Immune cell PD-L1 and adjuvant chemotherapy lost its prognostic significance in the tumoral PD-L1(+) and leptin(+) subgroups. Conclusions The prognostic implication of the variables may depend upon tumoral protein expression and the anatomical site. Immune cell PD-L1-positivity and the administration of adjuvant chemotherapy may indicate the favorable survival of patients with surgically-resected biliary tract cancers, specifically, in the tumoral PD-L1((-)) or tumor leptin((-)) subgroups and extrahepatic cholangiocarcinoma. PD-L1- or leptin-targeted therapy combined with conventional chemotherapy may benefit the tumoral PD-L1(+) or leptin(+) subgroups. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Prognostic roles of leptin-signaling proteins, PD-L1, and tumor-infiltrating lymphocytes in surgically-resected biliary tract cancers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jso.27140 | - |
dc.citation.journaltitle | Journal of Surgical Oncology | - |
dc.identifier.wosid | 000881733800001 | - |
dc.identifier.scopusid | 2-s2.0-85141952818 | - |
dc.citation.endpage | 597 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 587 | - |
dc.citation.volume | 127 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chang, Mee Soo | - |
dc.contributor.affiliatedAuthor | Kim, Won | - |
dc.contributor.affiliatedAuthor | Heo, Seung Chul | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GALLBLADDER CANCER | - |
dc.subject.keywordPlus | POTENTIAL ROLE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | OB-RB | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordAuthor | biliary tract cancer | - |
dc.subject.keywordAuthor | leptin | - |
dc.subject.keywordAuthor | PD-L1 | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | tumor-infiltrating lymphocytes | - |
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