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Prognostic roles of leptin-signaling proteins, PD-L1, and tumor-infiltrating lymphocytes in surgically-resected biliary tract cancers

DC Field Value Language
dc.contributor.authorByeon, Sun-ju-
dc.contributor.authorChang, Mee Soo-
dc.contributor.authorCho, Hwa Jin-
dc.contributor.authorPark, Jeong Hwan-
dc.contributor.authorKim, Ki Hwan-
dc.contributor.authorPark, Jin Hyun-
dc.contributor.authorChoi, In Sil-
dc.contributor.authorKim, Won-
dc.contributor.authorHan, Dong-Seok-
dc.contributor.authorAhn, Hye Seong-
dc.contributor.authorHeo, Seung Chul-
dc.date.accessioned2024-05-16T01:30:22Z-
dc.date.available2024-05-16T01:30:22Z-
dc.date.created2023-05-04-
dc.date.created2023-05-04-
dc.date.created2023-05-04-
dc.date.created2023-05-04-
dc.date.issued2023-03-
dc.identifier.citationJournal of Surgical Oncology, Vol.127 No.4, pp.587-597-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://hdl.handle.net/10371/202595-
dc.description.abstractBackground Biliary tract cancers are rare, with a poor patient prognosis. Leptin and programmed death-ligand 1 (PD-L1) influence CD8(+) and forkhead box P3 (FOXP3)(+) lymphocytes, and thus, cancer cell growth. We aimed to define the prognostic implications of these variables and the clinicopathological features of biliary tract cancers. Methods Immunohistochemistry for leptin signaling-related proteins (leptin, leptin receptor, pSTAT3, extracellular-regulated kinase, mammalian target of rapamycin), PD-L1, CD8, and FOXP3 and in situ hybridization for Epstein-Barr virus-encoded small RNAs were performed in 147 cases of surgically-resected biliary tract cancers. Results Immune cell PD-L1-positivity, tumor size < 3 cm, adjuvant chemotherapy, no recurrence, and early-stage tumors were correlated with better 5-year survival in the tumoral PD-L1((-)) and leptin((-)) subgroups, and extrahepatic cholangiocarcinoma through multivariate analysis (all p < 0.05). Immune cell PD-L1 and adjuvant chemotherapy lost its prognostic significance in the tumoral PD-L1(+) and leptin(+) subgroups. Conclusions The prognostic implication of the variables may depend upon tumoral protein expression and the anatomical site. Immune cell PD-L1-positivity and the administration of adjuvant chemotherapy may indicate the favorable survival of patients with surgically-resected biliary tract cancers, specifically, in the tumoral PD-L1((-)) or tumor leptin((-)) subgroups and extrahepatic cholangiocarcinoma. PD-L1- or leptin-targeted therapy combined with conventional chemotherapy may benefit the tumoral PD-L1(+) or leptin(+) subgroups.-
dc.language영어-
dc.publisherJohn Wiley & Sons Inc.-
dc.titlePrognostic roles of leptin-signaling proteins, PD-L1, and tumor-infiltrating lymphocytes in surgically-resected biliary tract cancers-
dc.typeArticle-
dc.identifier.doi10.1002/jso.27140-
dc.citation.journaltitleJournal of Surgical Oncology-
dc.identifier.wosid000881733800001-
dc.identifier.scopusid2-s2.0-85141952818-
dc.citation.endpage597-
dc.citation.number4-
dc.citation.startpage587-
dc.citation.volume127-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorChang, Mee Soo-
dc.contributor.affiliatedAuthorKim, Won-
dc.contributor.affiliatedAuthorHeo, Seung Chul-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusGALLBLADDER CANCER-
dc.subject.keywordPlusPOTENTIAL ROLE-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusT-CELLS-
dc.subject.keywordPlusOB-RB-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCHOLANGIOCARCINOMA-
dc.subject.keywordPlusMETASTASIS-
dc.subject.keywordPlusPROMOTES-
dc.subject.keywordPlusINVASION-
dc.subject.keywordAuthorbiliary tract cancer-
dc.subject.keywordAuthorleptin-
dc.subject.keywordAuthorPD-L1-
dc.subject.keywordAuthorprognosis-
dc.subject.keywordAuthortumor-infiltrating lymphocytes-
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