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Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors

Kwon, Yoo-Wook; Ahn, Hyo-Suk; Park, Joo-Young; Yang, Han-Mo; Cho, Hyun-Jai; Kim, Hyo-Soo

Issue Date
2018-01
Publisher
생화학분자생물학회
Citation
BMB Reports, Vol.51 No.5, pp.242-248
Abstract
Induced pluripotent stem cells (iPSCs) show great promise for replacing current stem cell therapies in the field of regenerative medicine. However, the original method for cellular reprogramming, involving four exogenous transcription factors, is characterized by low efficiency. Here, we focused on using epigenetic modifications to enhance the reprogramming efficiency. We hypothesized that there would be a new reprogramming factor involved in DNA demethylation, acting on the promoters of pluripotency-related genes. We screened proteins that bind to the methylated promoter of Oct4 and identified Zinc finger protein 127 (Zfp127), the functions of which have not yet been identified. We found that Zfp127 binds to the Oct4 promoter. Overexpression of Zfp127 in fibroblasts induced demethylation of the Oct4 promoter, thus enhancing Oct4 promoter activity and gene expression. These results demonstrate that Zfp127 is a novel regulator of Oct4, and may become a potent target to improve cellular reprogramming.
ISSN
1976-6696
URI
https://hdl.handle.net/10371/202754
DOI
https://doi.org/10.5483/BMBRep.2018.51.5.196
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