Detailed Information

Interleukin-6 expands homeostatic space for peripheral T cells

Cited 13 time in Web of Science Cited 12 time in Scopus

Hong, Changwan; Nam, Anna S.; Keller, Hilary R.; Ligons, Davinna L.; Park, Joo-Young; Yoon, Hee-Won; Park, Joseph J.; Luckey, Megan A.; Park, Jung-Hyun

Issue Date
Academic Press
Cytokine, Vol.64 No.2, pp.532-540
T cell homeostasis and survival is dependent on interleukin-7 (IL-7). Immune activation, however, downregulates IL-7 receptor expression on T cells so that T cell survival during activation must be maintained independently of IL-7. The pro-inflammatory cytokine IL-6 shares common signaling pathways with IL-7 and can promote T cell survival in vitro. But whether IL-6 promotes T cell survival and homeostasis in vivo is not clear. Notably, IL-6 overexpression results in massive plasmacytosis and autoimmunity so that an IL-6 effect on in vivo T cell survival has remained untested. To overcome this limitation, here we generated IL-6 transgenic mice on an immunoglobulin heavy chain (IgH) deficient background which rendered them B cell deficient. Notably, such IgH(KO)IL6(Tg) mice were free of any signs of inflammation or autoimmunity and remained healthy throughout the course of analysis. In these mice, we found that IL-6 overexpression significantly increased peripheral T cell numbers, but importantly without increasing thymopoiesis. Moreover, IL-6 signaled T cells maintained their naive phenotype and did not express activation/memory markers, suggesting that increased T cell numbers were due to increased T cell survival and not because of expansion of activated T cells. Mechanistically, we found that IL-6 signaling induced expression of pro-survival factors Mcl-1 and Pim-1/-2 but not Bcl-2. Thus, IL-6 is a T cell homeostatic cytokine that expands T cell space and can maintain the naive T cell pool. Published by Elsevier Ltd.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • School of Dentistry
  • Department of Dentistry
Research Area 구강 및 턱뼈 (구강악안면) 의 면역 항상성 유지기전에 대한 연구


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.