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Inflammation Confers Healing Advantage to Corneal Epithelium Following Subsequent Injury
Cited 2 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2023-02
- Citation
- International Journal of Molecular Sciences, Vol.24 No.4, p. 24043329
- Abstract
- Recent evidence shows that epithelial stem/progenitor cells in barrier tissues such as the skin, airways and intestines retain a memory of previous injuries, which enables tissues to accelerate barrier restoration after subsequent injuries. The corneal epithelium, the outermost layer of the cornea, is the frontline barrier for the eye and is maintained by epithelial stem/progenitor cells in the limbus. Herein, we provide evidence that inflammatory memory also exists in the cornea. In mice, eyes that had been exposed to corneal epithelial injury exhibited faster re-epithelialization of the cornea and lower levels of inflammatory cytokines following subsequent injury (either the same or a different type of injury) relative to naive eyes without previous injury. In ocular Sjogren's syndrome patients, corneal punctate epithelial erosions were significantly reduced after experiencing infectious injury compared with before. These results demonstrate that previous exposure of the corneal epithelium to inflammatory stimuli enhances corneal wound healing in response to a secondary assault, a phenomenon which points to the presence of nonspecific inflammatory memory in the cornea.
- ISSN
- 1661-6596
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