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Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ko, Jung Hwa | - |
dc.contributor.author | Kim, Hyeon Ji | - |
dc.contributor.author | Jeong, Hyun Jeong | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Oh, Joo Youn | - |
dc.date.accessioned | 2024-05-16T01:45:37Z | - |
dc.date.available | 2024-05-16T01:45:37Z | - |
dc.date.created | 2020-05-13 | - |
dc.date.created | 2020-05-13 | - |
dc.date.created | 2020-05-13 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | Cell Reports, Vol.30 No.11, pp.3806-3820.e6 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202830 | - |
dc.description.abstract | The cross-talk between mesenchymal stem and stromal cells (MSCs) and macrophages is critical for the restoration of tissue homeostasis after injury. Here, we demonstrate a pathway through which MSCs instruct macrophages to resolve inflammation and preserve tissue-specific stem cells, leading to homeostasis in mice with autoimmune uveoretinitis and sterile-injury-induced corneal epithelial stem cell deficiency. Distinct from their conventional role in macro-phage reprogramming to anti-inflammatory phenotype by a PGE2-dependent mechanism, MSCs enhance the phagocytic activity of macrophages, which partly depends on the uptake of MSC mitochondria-containing extracellular vesicles. The MSC-primed macrophages increase the secretion of amphiregulin (AREG) in a phagocytosis-dependent manner. AREG is essential for MSC-primed macrophages to suppress immune responses through regulatory T (Treg) cells and to protect corneal epithelial stem cells via apoptosis inhibition and proliferation promotion. Hence, the data reveal that MSCs harness macrophage-derived AREG to maintain tissue homeostasis after injury and provide a therapeutic target in immune-mediated disease and regenerative medicine. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.celrep.2020.02.062 | - |
dc.citation.journaltitle | Cell Reports | - |
dc.identifier.wosid | 000520843300021 | - |
dc.identifier.scopusid | 2-s2.0-85081691334 | - |
dc.citation.endpage | 3820.e6 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 3806 | - |
dc.citation.volume | 30 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | MITOCHONDRIAL TRANSFER | - |
dc.subject.keywordPlus | SUPPRESSIVE FUNCTION | - |
dc.subject.keywordPlus | DEXTRAN SULFATE | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | amphiregulin | - |
dc.subject.keywordAuthor | autoimmune uveoretinitis | - |
dc.subject.keywordAuthor | corneal epithelial stem cell | - |
dc.subject.keywordAuthor | extracellular vesicle | - |
dc.subject.keywordAuthor | homeostasis | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | mesenchymal stem and stromal cell | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.subject.keywordAuthor | prostaglandin E2 | - |
dc.subject.keywordAuthor | regulatory T cell | - |
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