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Data against a common assumption: Xenogeneic mouse models can be used to assay suppression of immunity by human MSCs

Cited 24 time in Web of Science Cited 26 time in Scopus
Authors

Prockop, Darwin J.; Oh, Joo Youn; Lee, Ryang Hwa

Issue Date
2017-08
Publisher
Nature Publishing Group
Citation
Molecular Therapy, Vol.25 No.8, pp.1748-1756
Abstract
Much of what we know about immunology suggests that little is to be gained from experiments in which human cells are administered to immunocompetent mice. Multiple "reports have demonstrated that this common assumption does not hold for experiments with human mesenchymal stem/stromal cells (hMSCs). The data demonstrate that hMSCs can suppress immune responses to a variety of stimuli in immunocompetent mice by a range of different mechanisms that are similar to those employed by mouse MSCs. Therefore, further experiments with hMSCs in mice will make it possible to generate preclinical data that will improve both the efficacy and safety of the clinical trials with the cells that are now in progress.
ISSN
1525-0016
URI
https://hdl.handle.net/10371/202866
DOI
https://doi.org/10.1016/j.ymthe.2017.06.004
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  • College of Medicine
  • Department of Medicine
Research Area 각막 및 외안부 질환, 백내장

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