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Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye
DC Field | Value | Language |
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dc.contributor.author | Ko, Jung Hwa | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Jeong, Hyun Jeong | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.contributor.author | Wee, Won Ryang | - |
dc.contributor.author | Yoon, Sun-ok | - |
dc.contributor.author | Choi, Hosoon | - |
dc.contributor.author | Prockop, Darwin J. | - |
dc.contributor.author | Oh, Joo Youn | - |
dc.date.accessioned | 2024-05-16T01:48:39Z | - |
dc.date.available | 2024-05-16T01:48:39Z | - |
dc.date.created | 2018-08-17 | - |
dc.date.created | 2018-08-17 | - |
dc.date.created | 2018-08-17 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, Vol.113 No.1, pp.158-163 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202882 | - |
dc.description.abstract | Intravenously administered mesenchymal stem/stromal cells (MSCs) engraft only transiently in recipients, but confer long-term therapeutic benefits in patients with immune disorders. This suggests that MSCs induce immune tolerance by long-lasting effects on the recipient immune regulatory system. Here, we demonstrate that i.v. infusion of MSCs preconditioned lung monocytes/macrophages toward an immune regulatory phenotype in a TNF-alpha-stimulated gene/protein (TSG)-6-dependent manner. As a result, mice were protected against subsequent immune challenge in two models of alloand autoimmune ocular inflammation: corneal allotransplantation and experimental autoimmune uveitis (EAU). The monocytes/macrophages primed by MSCs expressed high levels of MHC class II, B220, CD11b, and IL-10, and exhibited T-cell-suppressive activities independently of FoxP3(+) regulatory T cells. Adoptive transfer of MSC-induced B220(+) CD11b(+) monocytes/macrophages prevented corneal allograft rejection and EAU. Deletion of monocytes/macrophages abrogated the MSC-induced tolerance. However, MSCs with TSG-6 knockdown did not induce MHC II+ B220(+) CD11b(+) cells, and failed to attenuate EAU. Therefore, the results demonstrate a mechanism of the MSC-mediated immune modulation through induction of innate immune tolerance that involves monocytes/macrophages. | - |
dc.language | 영어 | - |
dc.publisher | National Academy of Sciences | - |
dc.title | Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye | - |
dc.type | Article | - |
dc.identifier.doi | 10.1073/pnas.1522905113 | - |
dc.citation.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.identifier.wosid | 000367520400049 | - |
dc.identifier.scopusid | 2-s2.0-84953330336 | - |
dc.citation.endpage | 163 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 158 | - |
dc.citation.volume | 113 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Mee Kum | - |
dc.contributor.affiliatedAuthor | Wee, Won Ryang | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY PROTEIN TSG-6 | - |
dc.subject.keywordPlus | REGULATORY T-CELLS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MSCS | - |
dc.subject.keywordPlus | HMSCS | - |
dc.subject.keywordPlus | PROSTAGLANDIN-E2 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | corneal allotransplantation | - |
dc.subject.keywordAuthor | experimental autoimmune uveitis | - |
dc.subject.keywordAuthor | immune tolerance | - |
dc.subject.keywordAuthor | mesenchymal stem/stromal cell | - |
dc.subject.keywordAuthor | monocyte/macrophage | - |
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