Publications
Detailed Information
Intravitreal TSG-6 suppresses laser-induced choroidal neovascularization by inhibiting CCR2+ monocyte recruitment : Intravitreal TSG-6 suppresses laser-induced choroidal neovascularization by inhibiting CCR2(+) monocyte recruitment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sang Jin | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Yun, Ji-Hyun | - |
dc.contributor.author | Ko, Jung Hwa | - |
dc.contributor.author | Choi, Da Ye | - |
dc.contributor.author | Oh, Joo Youn | - |
dc.date.accessioned | 2024-05-16T01:48:50Z | - |
dc.date.available | 2024-05-16T01:48:50Z | - |
dc.date.created | 2018-11-26 | - |
dc.date.created | 2018-11-26 | - |
dc.date.created | 2018-11-26 | - |
dc.date.created | 2018-11-26 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | Scientific Reports, Vol.5, p. 11872 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202885 | - |
dc.description.abstract | Choroidal neovascularization (CNV) is the hallmark of wet age-related macular degeneration (AMD), one of the leading causes of blindness in the elderly. Although the pathogenesis of CNV is not clear, a number of studies show that ocular-infiltrating macrophages and inflammation play a critical role in the development of CNV. TNF alpha-stimulated gene/protein (TSG)-6 is a multifunctional endogenous protein that has anti-inflammatory activities partly by regulating macrophage activation. Therefore, we here investigated the therapeutic potential of TSG-6 in a rat model of CNV induced by laser photocoagulation. Time course analysis showed that the expression of VEGF and pro-inflammatory cytokines in the choroid was up-regulated early after laser injury, and gradually decreased to baseline over 14 days. An intravitreal injection of TSG-6 suppressed the expression of VEGF and pro-inflammatory cytokines including CCL2, and reduced the size of CNV. Also, the number of Iba(+) and CCR2(+) cells including infiltrating macrophages was markedly lower in the CNV lesion of TSG-6-treated eyes. Further analysis identified CCR2(+) CD11b(+) CD11c(+) cells and CCR2(+) CD11b(-)CD11c(+) cells as the cell populations that were increased by laser injury and reduced by TSG-6 treatment. Together, the results demonstrate that TSG-6 inhibits inflammation and CCR2(+) monocyte recruitment into the choroid, and suppresses the development of CNV. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Intravitreal TSG-6 suppresses laser-induced choroidal neovascularization by inhibiting CCR2+ monocyte recruitment | - |
dc.title.alternative | Intravitreal TSG-6 suppresses laser-induced choroidal neovascularization by inhibiting CCR2(+) monocyte recruitment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/srep11872 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000357453600001 | - |
dc.identifier.scopusid | 2-s2.0-84936153603 | - |
dc.citation.startpage | 11872 | - |
dc.citation.volume | 5 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Oh, Joo Youn | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STERILE INFLAMMATION | - |
dc.subject.keywordPlus | MACULAR DEGENERATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | INFILTRATE | - |
dc.subject.keywordPlus | PROTEIN-1 | - |
dc.subject.keywordPlus | RECEPTOR | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.