Publications
Detailed Information
Photocatalytic C-O Coupling Enzymes That Operate via Intramolecular Electron Transfer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jaehee | - |
dc.contributor.author | Song, Woon Ju | - |
dc.date.accessioned | 2024-05-16T01:49:59Z | - |
dc.date.available | 2024-05-16T01:49:59Z | - |
dc.date.created | 2023-04-17 | - |
dc.date.created | 2023-04-17 | - |
dc.date.issued | 2023-02 | - |
dc.identifier.citation | Journal of the American Chemical Society, Vol.145 No.9, pp.5211-5221 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://hdl.handle.net/10371/202899 | - |
dc.description.abstract | Efficient and environmentally friendly conversion of light energy for direct utilization in chemical production has been a long-standing goal in enzyme design. Herein, we synthesized artificial photocatalytic enzymes by introducing an Ir photocatalyst and a Ni(bpy) complex to an optimal protein scaffold in close proximity. Consequently, the enzyme generated C-O coupling products with up to 96% yields by harvesting visible light and performing intramolecular electron transfer between the two catalysts. We systematically modulated the catalytic activities of the artificial photocatalytic cross-coupling enzymes by tuning the electrochemical properties of the catalytic components, their positions, and distances within a protein. As a result, we discovered the best-performing mutant that showed broad substrate scopes under optimized conditions. This work explicitly demonstrated that we could integrate and control both the inorganic and biochemical components of photocatalytic biocatalysis to achieve high yield and selectivity in valuable chemical transformations. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Photocatalytic C-O Coupling Enzymes That Operate via Intramolecular Electron Transfer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/jacs.2c12226 | - |
dc.citation.journaltitle | Journal of the American Chemical Society | - |
dc.identifier.wosid | 000947484700001 | - |
dc.identifier.scopusid | 2-s2.0-85148934378 | - |
dc.citation.endpage | 5221 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 5211 | - |
dc.citation.volume | 145 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Song, Woon Ju | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PHOTOINDUCED HYDROGEN-PRODUCTION | - |
dc.subject.keywordPlus | ENERGY-TRANSFER | - |
dc.subject.keywordPlus | PHOTOREDOX CATALYSIS | - |
dc.subject.keywordPlus | PHOTOSYSTEM-I | - |
dc.subject.keywordPlus | ARYL HALIDES | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RADIOLYSIS | - |
dc.subject.keywordPlus | CHEMISTRY | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.