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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes : Synergism of TNF-alpha and IFN-gamma Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Cited 419 time in Web of Science Cited 866 time in Scopus
Authors

Karki, Rajendra; Sharma, Bhesh Raj; Tuladhar, Shraddha; Williams, Evan Peter; Zalduondo, Lillian; Samir, Parimal; Zheng, Min; Sundaram, Balamurugan; Banoth, Balaji; Malireddi, R. K. Subbarao; Schreiner, Patrick; Neale, Geoffrey; Vogel, Peter; Webby, Richard; Jonsson, Colleen Beth; Kanneganti, Thirumala-Devi

Issue Date
2021-01
Publisher
Cell Press
Citation
Cell, Vol.184 No.1, pp.149-168.e17
Abstract
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute lung damage associated with patient mortality. While multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection, we found that only the combination of TNF-alpha and IFN-gamma induced inflammatory cell death characterized by inflammatory cell death, PANoptosis. Mechanistically, TNF-alpha and IFN-gamma co-treatment activated the JAK/STAT1/IRF1 axis, inducing nitric oxide production and driving caspase-8/FADD-mediated PANoptosis. TNF-alpha and IFN-gamma caused a lethal cytokine shock in mice that mirrors the tissue damage and inflammation of COVID-19, and inhibiting PANoptosis protected mice from this pathology and death. Furthermore, treating with neutralizing antibodies against TNF-alpha and IFN-gamma protected mice from mortality during SARS-CoV-2 infection, sepsis, hemophagocytic lymphohistiocytosis, and cytokine shock. Collectively, our findings suggest that blocking the cytokine-mediated inflammatory cell death signaling pathway identified here may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation.
ISSN
0092-8674
URI
https://hdl.handle.net/10371/203005
DOI
https://doi.org/10.1016/j.cell.2020.11.025
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  • College of Natural Sciences
  • School of Biological Sciences
Research Area Cytokine Storm, Host Defense, Innate Immunity in Metabolic and Inflammatory Diseases

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