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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zheng, Min | - |
dc.contributor.author | Karki, Rajendra | - |
dc.contributor.author | Vogel, Peter | - |
dc.contributor.author | Kanneganti, Thirumala-Devi | - |
dc.date.accessioned | 2024-05-16T01:57:11Z | - |
dc.date.available | 2024-05-16T01:57:11Z | - |
dc.date.created | 2023-05-09 | - |
dc.date.created | 2023-05-09 | - |
dc.date.created | 2023-05-09 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.citation | Cell, Vol.181 No.3, pp.674-687.e13 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203015 | - |
dc.description.abstract | Caspases regulate cell death, immune responses, and homeostasis. Caspase-6 is categorized as an executioner caspase but shows key differences from the other executioners, Overall, little is known about the functions of caspase-6 in biological processes apart from apoptosis. Here, we show that caspase-6 mediates innate immunity and inflammasome activation. Furthermore, we demonstrate that caspase-6 promotes the activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in host defense against influenza A virus (IAV) infection, In addition, caspase-6 promoted the differentiation of alternatively activated macrophages (AAMs). Caspase-6 facilitated the RIP homotypic interaction motif (RHIM)-dependent binding of RIPK3 to ZBP1 via its interaction with RIPK3. Altogether, our findings reveal a vital role for caspase-6 in facilitating ZBP1-mediated inflammasome activation, cell death, and host defense during IAV infection, opening additional avenues for treatment of infectious and autoinflammatory diseases and cancer. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cell.2020.03.040 | - |
dc.citation.journaltitle | Cell | - |
dc.identifier.wosid | 000530708400021 | - |
dc.identifier.scopusid | 2-s2.0-85083777875 | - |
dc.citation.endpage | 687.e13 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 674 | - |
dc.citation.volume | 181 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Karki, Rajendra | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MIXED LINEAGE KINASE | - |
dc.subject.keywordPlus | INFLUENZA-A VIRUS | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | DOMAIN-LIKE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | NLRP3 | - |
dc.subject.keywordPlus | NECROPTOSIS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | COMPLEX | - |
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