Publications
Detailed Information
Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhu, Qifan | - |
dc.contributor.author | Zheng, Min | - |
dc.contributor.author | Balakrishnan, Arjun | - |
dc.contributor.author | Karki, Rajendra | - |
dc.contributor.author | Kanneganti, Thirumala-Devi | - |
dc.date.accessioned | 2024-05-16T01:57:49Z | - |
dc.date.available | 2024-05-16T01:57:49Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.created | 2023-05-08 | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | Journal of Immunology, Vol.201 No.12, pp.3662-3668 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203027 | - |
dc.description.abstract | The DNA sensor absent in melanoma 2 (AIM2) forms an inflammasome complex with ASC and caspase-1 in response to Francisella tularensis subspecies novicida infection, leading to maturation of IL-1 beta and IL-18 and pyroptosis. AIM2 is critical for host protection against F. novicida infection in vivo; however, the role of pyroptosis downstream of the AIM2 inflammasome is unknown. Recent studies have identified gasdermin D (GSDMD) as the molecule executing pyroptosis by forming pores on the plasma membrane following activation by inflammatory caspase-1 and -11. In this study, we report that GSDMD-deficient mice were susceptible to F. novicida infection compared with wild type mice. Interestingly, we observed that GSDMD is required for optimal caspase-1 activation and pyroptotic cell death in F. novicida-infected bone marrow-derived macrophages. Furthermore, caspase-1 activation was compromised in bone marrow-derived macrophages lacking GSDMD stimulated with other AIM2 inflammasome triggers, including poly(dA:dT) transfection and mouse CMV infection. Overall, our study highlights a function, to our knowledge previously unknown, for GSDMD in promoting caspase-1 activation by AIM2 inflammasome. | - |
dc.language | 영어 | - |
dc.publisher | American Association of Immunologists | - |
dc.title | Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.1800788 | - |
dc.citation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | 000452626700019 | - |
dc.identifier.scopusid | 2-s2.0-85058407229 | - |
dc.citation.endpage | 3668 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 3662 | - |
dc.citation.volume | 201 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Karki, Rajendra | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | D PORE | - |
dc.subject.keywordPlus | PYROPTOSIS | - |
dc.subject.keywordPlus | GSDMD | - |
dc.subject.keywordPlus | TULARENSIS | - |
dc.subject.keywordPlus | CASPASE-11 | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | INFECTION | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.