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DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota

Cited 32 time in Web of Science Cited 30 time in Scopus
Authors

Man, Si Ming; Karki, Rajendra; Kanneganti, Thirumala-Devi

Issue Date
2016-06
Publisher
John Wiley & Sons Inc.
Citation
Pathogens and Disease, Vol.74 No.4, p. ftw028
Abstract
DNA sensors are formidable immune guardians of the host. At least 14 cytoplasmic DNA sensors have been identified in recent years, each with specialized roles in driving inflammation and/or cell death. Of these, AIM2 is a sensor of dsDNA, and forms an inflammasome complex to activate the cysteine protease caspase-1, mediates the release of the proinflammatory cytokines IL-1 beta and IL-18, and induces pyroptosis. The inflammasome sensor NLRP3 can also respond to DNA in the forms of oxidized mitochondrial DNA and the DNA derivative RNA: DNA hybrids produced by bacteria, whereas the putative inflammasome sensor IFI16 responds to viral DNA in the nucleus. Although inflammasomes provoke inflammation for anti-microbial host defense, they must also maintain homeostasis with commensal microbiota. Here, we outline recent advances highlighting the complex relationship between DNA-sensing inflammasomes, bacterial host defense and the gut microbiota.
ISSN
2049-632X
URI
https://hdl.handle.net/10371/203051
DOI
https://doi.org/10.1093/femspd/ftw028
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  • College of Natural Sciences
  • School of Biological Sciences
Research Area Cytokine Storm, Host Defense, Innate Immunity in Metabolic and Inflammatory Diseases

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