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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Man, Si Ming | - |
dc.contributor.author | Zhu, Qifan | - |
dc.contributor.author | Zhu, Liqin | - |
dc.contributor.author | Liu, Zhiping | - |
dc.contributor.author | Karki, Rajendra | - |
dc.contributor.author | Malik, Ankit | - |
dc.contributor.author | Sharma, Deepika | - |
dc.contributor.author | Li, Liyuan | - |
dc.contributor.author | Malireddi, R. K. Subbarao | - |
dc.contributor.author | Gurung, Prajwal | - |
dc.contributor.author | Neale, Geoffrey | - |
dc.contributor.author | Olsen, Scott R. | - |
dc.contributor.author | Carter, Robert A. | - |
dc.contributor.author | McGoldrick, Daniel J. | - |
dc.contributor.author | Wu, Gang | - |
dc.contributor.author | Finkelstein, David | - |
dc.contributor.author | Vogel, Peter | - |
dc.contributor.author | Gilbertson, Richard J. | - |
dc.contributor.author | Kanneganti, Thirumala-Devi | - |
dc.date.accessioned | 2024-05-16T01:59:26Z | - |
dc.date.available | 2024-05-16T01:59:26Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.created | 2023-05-08 | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2015-07 | - |
dc.identifier.citation | Cell, Vol.162 No.1, pp.45-58 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203058 | - |
dc.description.abstract | Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune sensor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Production of inflammasome-associated cytokines and other inflammatory mediators was largely intact in Aim2-deficient mice; however, intestinal stem cells were prone to uncontrolled proliferation. Aberrant Wnt signaling expanded a population of tumor-initiating stem cells in the absence of AIM2. Susceptibility of Aim2-deficient mice to colorectal tumorigenesis was enhanced by a dysbiotic gut microbiota, which was reduced by reciprocal exchange of gut microbiota with healthy wild-type mice. These findings uncover a synergy between a specific host genetic factor and gut microbiota in determining the susceptibility to colorectal cancer. Therapeutic modulation of AIM2 expression and microbiota has the potential to prevent colorectal cancer. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.cell.2015.06.001 | - |
dc.citation.journaltitle | Cell | - |
dc.identifier.wosid | 000357542300008 | - |
dc.identifier.scopusid | 2-s2.0-84934346989 | - |
dc.citation.endpage | 58 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 45 | - |
dc.citation.volume | 162 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Karki, Rajendra | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | MELANOMA 2 | - |
dc.subject.keywordPlus | NEGATIVE REGULATION | - |
dc.subject.keywordPlus | COLON INFLAMMATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | ABSENT | - |
dc.subject.keywordPlus | RECOGNITION | - |
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