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Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Kwang Hoon | - |
dc.contributor.author | Lee, Jaehyun | - |
dc.contributor.author | Jung, Hong-Ryul | - |
dc.contributor.author | Park, HyoungJun | - |
dc.contributor.author | Doh, Junsang | - |
dc.date.accessioned | 2024-05-17T07:37:21Z | - |
dc.date.available | 2024-05-17T07:37:21Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2017-09 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, Vol.7 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203166 | - |
dc.description.abstract | T cells navigate diverse microenvironments to perform immune responses. Micro-scale topographical structures within the tissues, which may inherently exist in normal tissues or may be formed by inflammation or injury, can influence T cell migration, but how T cell migration is affected by such topographical structures have not been investigated. In this study, we fabricated ramp-like structures with a 5 mu m height and various slopes, and observed T cells climbing up the ramp-like structures. T cells encountering the ramp-like structures exhibited MLC accumulation near head-tail junctions contacting the ramp-like structures, and made turns to the direction perpendicular to the ramp-like structures. Pharmacological study revealed that lamellipodia formation mediated by arp2/3 and contractility regulated by myosin light chain kinase (MLCK) were responsible for the intriguing turning behavior of T cells climbing the ramp-like structures. Arp2/3 or MLCK inhibition substantially reduced probability of T cells climbing sharp-edged ramp-like structures, indicating intriguing turning behavior of T cells mediated by lamellipodia formation and MLCK activity may be important for T cells to access inflamed or injured tissues with abrupt topographical changes. | - |
dc.language | 영어 | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-017-11938-y | - |
dc.citation.journaltitle | SCIENTIFIC REPORTS | - |
dc.identifier.wosid | 000410739000031 | - |
dc.identifier.scopusid | 2-s2.0-85029538611 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GUIDED MIGRATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | NANOTOPOGRAPHY | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | GUIDANCE | - |
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