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Negative role of inducible PD-1 on survival of activated dendritic cells
DC Field | Value | Language |
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dc.contributor.author | Park, Seong Jeong | - |
dc.contributor.author | Namkoong, Hong | - |
dc.contributor.author | Doh, Junsang | - |
dc.contributor.author | Choi, Jong-Cheol | - |
dc.contributor.author | Yang, Bo-Gie | - |
dc.contributor.author | Park, Yunji | - |
dc.contributor.author | Chul Sung, Young | - |
dc.date.accessioned | 2024-05-20T00:42:16Z | - |
dc.date.available | 2024-05-20T00:42:16Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | Journal of Leukocyte Biology, Vol.95 No.4, pp.621-629 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203403 | - |
dc.description.abstract | PD-1 expressed on activated DCs suppresses T cell activation via decreasing DC survival. PD-1 is a well-established negative regulator of T cell responses by inhibiting proliferation and cytokine production of T cells via interaction with its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2), expressed on non-T cells. Recently, PD-1 was found to be expressed in innate cells, including activated DCs, and plays roles in suppressing production of inflammatory cytokines. In this study, we demonstrate that PD-1 KO DCs exhibited prolonged longevity compared with WT DCs in the dLNs after transfer of DCs into hind footpads. Interestingly, upon LPS stimulation, WT DCs increased the expression of PD-1 and started to undergo apoptosis. DCs, in spleen of LPS-injected PD-1 KO mice, were more resistant to LPS-mediated apoptosis in vivo than WT controls. Moreover, treatment of blocking anti-PD-1 mAb during DC maturation resulted in enhanced DC survival, suggesting that PD-1:PD-L interactions are involved in DC apoptosis. As a result, PD-1-deficient DCs augmented T cell responses in terms of antigen-specific IFN- production and proliferation of CD4 and CD8 T cells to a greater degree than WT DCs. Moreover, PD-1 KO DCs exhibited increased MAPK1 and CD40-CD40L signaling, suggesting a possible mechanism for enhanced DC survival in the absence of PD-1 expression. Taken together, our findings further extend the function of PD-1, which plays an important role in apoptosis of activated DCs and provides important implications for PD-1-mediated immune regulation. | - |
dc.language | 영어 | - |
dc.publisher | Federation of American Societies for Experimental Biology | - |
dc.title | Negative role of inducible PD-1 on survival of activated dendritic cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1189/jlb.0813443 | - |
dc.citation.journaltitle | Journal of Leukocyte Biology | - |
dc.identifier.wosid | 000335346300007 | - |
dc.identifier.scopusid | 2-s2.0-84899865906 | - |
dc.citation.endpage | 629 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 621 | - |
dc.citation.volume | 95 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | MHC CLASS-II | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | ANTI-PD-1 ANTIBODY | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | LYMPH-NODES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | immune regulator | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | inhibitory | - |
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