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Ethanol-Dispersed Polymer Nanofibers as a Highly Selective Cell Isolation and Release Platform for CD4+ T Lymphocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jun, Seung-Hyun | - |
dc.contributor.author | Kim, Kwanghee | - |
dc.contributor.author | An, Hyo Jin | - |
dc.contributor.author | Kim, Byoung Chan | - |
dc.contributor.author | Sonn, Chung Hee | - |
dc.contributor.author | Kim, Miju | - |
dc.contributor.author | Doh, Junsang | - |
dc.contributor.author | Yee, Cassian | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.contributor.author | Kim, Jungbae | - |
dc.date.accessioned | 2024-05-20T00:42:51Z | - |
dc.date.available | 2024-05-20T00:42:51Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2012-11 | - |
dc.identifier.citation | Advanced Functional Materials, Vol.22 No.21, pp.4448-4455 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://hdl.handle.net/10371/203414 | - |
dc.description.abstract | A novel cell isolation and release platform using electrospun polystyrene-poly(styrene-co-maleic anhydride) (PS-PSMA) nanofibers is presented. Ethanol treatment of PS-PSMA nanofibers, employed for the purpose of sterilization, significantly increases their inter-fiber space for both antibody conjugation and subsequent cell separation. For the selective isolation of CD4(+) T cells from heterogeneous mixtures of mouse lymph nodes, capture efficiencies of up to 100% are achieved while maintaining cellular integrity and viability. Once captured, CD4(+) T lymphocytes can also be released from the NF scaffolds, further demonstrating its potential functionality as an immune cell-supporting and releasing matrix. This is the first demonstration of lymphocyte-culture scaffolds enabling selective isolation, accommodation, and sustained release of CD4(+) T cells for the purpose of cell therapies. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Ethanol-Dispersed Polymer Nanofibers as a Highly Selective Cell Isolation and Release Platform for CD4+ T Lymphocytes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adfm.201200657 | - |
dc.citation.journaltitle | Advanced Functional Materials | - |
dc.identifier.wosid | 000310602700006 | - |
dc.identifier.scopusid | 2-s2.0-84868537746 | - |
dc.citation.endpage | 4455 | - |
dc.citation.number | 21 | - |
dc.citation.startpage | 4448 | - |
dc.citation.volume | 22 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ELECTROSPUN | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | COATINGS | - |
dc.subject.keywordPlus | HER2/NEU | - |
dc.subject.keywordAuthor | electrospun polymer nanofibers | - |
dc.subject.keywordAuthor | ethanol dispersion | - |
dc.subject.keywordAuthor | CD4+T lymphocyte | - |
dc.subject.keywordAuthor | cell separation | - |
dc.subject.keywordAuthor | cell transplantation | - |
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