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Study on the role of microtubules on T cell migration under confined environments

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dc.contributor.authorPark, HyoungJun-
dc.contributor.authorDoh, Junsang-
dc.date.accessioned2024-05-20T06:14:11Z-
dc.date.available2024-05-20T06:14:11Z-
dc.date.created2024-05-20-
dc.date.issued2015-
dc.identifier.citationBiomedical Engineering Letters, Vol.5 No.3, pp.188-193-
dc.identifier.issn2093-9868-
dc.identifier.urihttps://hdl.handle.net/10371/203480-
dc.description.abstractPurpose: Migration of T cells is critical for immune surveillance and immune responses. Microtubule is the largest cytoskeleton and it is highly related with cell migration, but the role of microtubule on T cell migration under confined environments, which is an emergent property of interstitial spaces in vivo for leukocyte migration, has not been studied. Methods: In this study, we first fabricated two different types of microchannels, wide microchannels (WMCs) that only confines T cells in vertical direction, and narrow microchannels (NMCs) that confines T cells in both vertical and horizontal directions. Then, morphology, velocity, and directional persistence of T cells in the different confined conditions were quantitatively analyzed. In addition, pharmacological inhibitors modulating microtubule stability were used to assess the roles of microtubule dynamics on T cell migration under confinement. Results: T cells within microchannels were tightly confined, exhibiting flattened or elongated morphologies depending on whether they were in WMCs or NMCs. Velocity and directional persistent of T cells increased as the degree of confinement increased. In addition, Taxol-treatment significantly reduced directional persistence of T cells under confined environments. Conclusions Dynamics of microtubule played an important role in the directional persistency of T cells in confined environments.-
dc.language영어-
dc.publisherSpringer Verlag-
dc.titleStudy on the role of microtubules on T cell migration under confined environments-
dc.typeArticle-
dc.identifier.doi10.1007/s13534-015-0197-8-
dc.citation.journaltitleBiomedical Engineering Letters-
dc.identifier.scopusid2-s2.0-84944451882-
dc.citation.endpage193-
dc.citation.number3-
dc.citation.startpage188-
dc.citation.volume5-
dc.identifier.kciidART002037884-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorDoh, Junsang-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordAuthorCell migration-
dc.subject.keywordAuthorConfinement-
dc.subject.keywordAuthorMicrotubule-
dc.subject.keywordAuthorPharmacological inhibitor-
dc.subject.keywordAuthorT cell-
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  • College of Engineering
  • Department of Materials Science & Engineering
Research Area Ex Vivo Models, Lymphocyte Biology, Smart Biomaterials

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