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Study on the role of microtubules on T cell migration under confined environments
DC Field | Value | Language |
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dc.contributor.author | Park, HyoungJun | - |
dc.contributor.author | Doh, Junsang | - |
dc.date.accessioned | 2024-05-20T06:14:11Z | - |
dc.date.available | 2024-05-20T06:14:11Z | - |
dc.date.created | 2024-05-20 | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Biomedical Engineering Letters, Vol.5 No.3, pp.188-193 | - |
dc.identifier.issn | 2093-9868 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203480 | - |
dc.description.abstract | Purpose: Migration of T cells is critical for immune surveillance and immune responses. Microtubule is the largest cytoskeleton and it is highly related with cell migration, but the role of microtubule on T cell migration under confined environments, which is an emergent property of interstitial spaces in vivo for leukocyte migration, has not been studied. Methods: In this study, we first fabricated two different types of microchannels, wide microchannels (WMCs) that only confines T cells in vertical direction, and narrow microchannels (NMCs) that confines T cells in both vertical and horizontal directions. Then, morphology, velocity, and directional persistence of T cells in the different confined conditions were quantitatively analyzed. In addition, pharmacological inhibitors modulating microtubule stability were used to assess the roles of microtubule dynamics on T cell migration under confinement. Results: T cells within microchannels were tightly confined, exhibiting flattened or elongated morphologies depending on whether they were in WMCs or NMCs. Velocity and directional persistent of T cells increased as the degree of confinement increased. In addition, Taxol-treatment significantly reduced directional persistence of T cells under confined environments. Conclusions Dynamics of microtubule played an important role in the directional persistency of T cells in confined environments. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Study on the role of microtubules on T cell migration under confined environments | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13534-015-0197-8 | - |
dc.citation.journaltitle | Biomedical Engineering Letters | - |
dc.identifier.scopusid | 2-s2.0-84944451882 | - |
dc.citation.endpage | 193 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 188 | - |
dc.citation.volume | 5 | - |
dc.identifier.kciid | ART002037884 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Cell migration | - |
dc.subject.keywordAuthor | Confinement | - |
dc.subject.keywordAuthor | Microtubule | - |
dc.subject.keywordAuthor | Pharmacological inhibitor | - |
dc.subject.keywordAuthor | T cell | - |
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