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Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells

DC Field Value Language
dc.contributor.authorKim, Tae-Jin-
dc.contributor.authorKim, Miju-
dc.contributor.authorKim, Hye Mi-
dc.contributor.authorLim, Seon Ah-
dc.contributor.authorKim, Eun-Ok-
dc.contributor.authorKim, Kwanghee-
dc.contributor.authorSong, Kwang Hoon-
dc.contributor.authorKim, Jiyoung-
dc.contributor.authorKumar, Vinay-
dc.contributor.authorYee, Cassian-
dc.contributor.authorDoh, Junsang-
dc.contributor.authorLee, Kyung-Mi-
dc.date.accessioned2024-05-20T06:14:17Z-
dc.date.available2024-05-20T06:14:17Z-
dc.date.created2024-05-17-
dc.date.issued2014-12-
dc.identifier.citationScientific Reports, Vol.4-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://hdl.handle.net/10371/203482-
dc.description.abstractWhile stationary organ cells are in continuous contact with neighboring cells, immune cells circulate throughout the body without an apparent requirement for cell-cell contact to persist in vivo. This study challenges current convention by demonstrating, both in vitro and in vivo, that innate immune NK cells can engage in homotypic NK-to-NK cell interactions for optimal survival, activation, and proliferation. Using a specialized cell-laden microwell approach, we discover that NK cells experiencing constant NK-to-NK contact exhibit a synergistic increase in activation status, cell proliferation, and anti-tumor function in response to IL-2 or IL-15. This effect is dependent on 2B4/CD48 ligation and an active cytoskeleton, resulting in amplification of IL-2 receptor signaling, enhanced CD122/CD132 colocalization, CD25 upregulation, and Stat3 activation. Conversely, 'orphan' NK cells demonstrate no such synergy and fail to persist. Therefore, our data uncover the existence of homotypic cell-to-cell communication among mobile innate lymphocytes, which promotes functional synergy within the cytokine-rich microenvironment.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleHomotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells-
dc.typeArticle-
dc.identifier.doi10.1038/srep07157-
dc.citation.journaltitleScientific Reports-
dc.identifier.wosid000346269100001-
dc.identifier.scopusid2-s2.0-84923348290-
dc.citation.volume4-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorDoh, Junsang-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusNATURAL-KILLER-CELLS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusCYTOTOXICITY-
dc.subject.keywordPlusRECOGNITION-
dc.subject.keywordPlusSENSITIVITY-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusSIGNALS-
dc.subject.keywordPlusCD244-
dc.subject.keywordPlusEAT-2-
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  • College of Engineering
  • Department of Materials Science & Engineering
Research Area Ex Vivo Models, Lymphocyte Biology, Smart Biomaterials

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