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Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae-Jin | - |
dc.contributor.author | Kim, Miju | - |
dc.contributor.author | Kim, Hye Mi | - |
dc.contributor.author | Lim, Seon Ah | - |
dc.contributor.author | Kim, Eun-Ok | - |
dc.contributor.author | Kim, Kwanghee | - |
dc.contributor.author | Song, Kwang Hoon | - |
dc.contributor.author | Kim, Jiyoung | - |
dc.contributor.author | Kumar, Vinay | - |
dc.contributor.author | Yee, Cassian | - |
dc.contributor.author | Doh, Junsang | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.date.accessioned | 2024-05-20T06:14:17Z | - |
dc.date.available | 2024-05-20T06:14:17Z | - |
dc.date.created | 2024-05-17 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | Scientific Reports, Vol.4 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203482 | - |
dc.description.abstract | While stationary organ cells are in continuous contact with neighboring cells, immune cells circulate throughout the body without an apparent requirement for cell-cell contact to persist in vivo. This study challenges current convention by demonstrating, both in vitro and in vivo, that innate immune NK cells can engage in homotypic NK-to-NK cell interactions for optimal survival, activation, and proliferation. Using a specialized cell-laden microwell approach, we discover that NK cells experiencing constant NK-to-NK contact exhibit a synergistic increase in activation status, cell proliferation, and anti-tumor function in response to IL-2 or IL-15. This effect is dependent on 2B4/CD48 ligation and an active cytoskeleton, resulting in amplification of IL-2 receptor signaling, enhanced CD122/CD132 colocalization, CD25 upregulation, and Stat3 activation. Conversely, 'orphan' NK cells demonstrate no such synergy and fail to persist. Therefore, our data uncover the existence of homotypic cell-to-cell communication among mobile innate lymphocytes, which promotes functional synergy within the cytokine-rich microenvironment. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/srep07157 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000346269100001 | - |
dc.identifier.scopusid | 2-s2.0-84923348290 | - |
dc.citation.volume | 4 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Doh, Junsang | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | CD244 | - |
dc.subject.keywordPlus | EAT-2 | - |
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