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Metals in Protein-Protein Interfaces

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dc.contributor.authorSong, Woon Ju-
dc.contributor.authorSontz, Pamela A.-
dc.contributor.authorAmbroggio, Xavier I.-
dc.contributor.authorTezcan, F. Akif-
dc.date.accessioned2024-05-20T06:14:24Z-
dc.date.available2024-05-20T06:14:24Z-
dc.date.created2024-05-20-
dc.date.created2024-05-20-
dc.date.issued2014-05-
dc.identifier.citationAnnual Review of Biophysics, Vol.43, pp.409-431-
dc.identifier.issn1936-122X-
dc.identifier.urihttps://hdl.handle.net/10371/203484-
dc.description.abstractFrom the catalytic reactions that sustain the global oxygen, nitrogen, and carbon cycles to the stabilization of DNA processing proteins, transition metal ions and metallocofactors play key roles in biology. Although the exquisite interplay between metal ions and protein scaffolds has been studied extensively, the fact that the biological roles of the metals often stem from their placement in the interfaces between proteins and protein subunits is not always recognized. Interfacial metal ions stabilize permanent or transient protein-protein interactions, enable protein complexes involved in cellular signaling to adopt distinct conformations in response to environmental stimuli, and catalyze challenging chemical reactions that are uniquely performed by multisubunit protein complexes. This review provides a structural survey of transition metal ions and metallocofactors found in protein-protein interfaces, along with a series of selected examples that illustrate their diverse biological utility and significance.-
dc.language영어-
dc.publisherAnnual Reviews, Inc.-
dc.titleMetals in Protein-Protein Interfaces-
dc.typeArticle-
dc.identifier.doi10.1146/annurev-biophys-051013-023038-
dc.citation.journaltitleAnnual Review of Biophysics-
dc.identifier.wosid000348434000018-
dc.identifier.scopusid2-s2.0-84901985721-
dc.citation.endpage431-
dc.citation.startpage409-
dc.citation.volume43-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorSong, Woon Ju-
dc.type.docTypeReview; Book Chapter-
dc.description.journalClass1-
dc.subject.keywordPlusZINC TRANSPORTER YIIP-
dc.subject.keywordPlusCARBON-MONOXIDE DEHYDROGENASE-
dc.subject.keywordPlusRAY CRYSTAL-STRUCTURE-
dc.subject.keywordPlusHUMAN INSULIN HEXAMER-
dc.subject.keywordPlusALPHA-BETA-TUBULIN-
dc.subject.keywordPlusSTRUCTURAL BASIS-
dc.subject.keywordPlusBINDING-SITE-
dc.subject.keywordPlusMETHANOSARCINA-THERMOPHILA-
dc.subject.keywordPlusCRYSTALLOGRAPHIC EVIDENCE-
dc.subject.keywordPlusRHODOSPIRILLUM-RUBRUM-
dc.subject.keywordAuthormetal/metallocofactors-
dc.subject.keywordAuthorprotein-protein interactions-
dc.subject.keywordAuthorprotein self-assembly-
dc.subject.keywordAuthorinterfacial metal clusters-
dc.subject.keywordAuthormetal-mediated oligomerization-
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  • College of Natural Sciences
  • Department of Chemistry
Research Area Biochemistry, Inorganic, 무기화학, 생화학

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