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Oxidizing intermediates in cytochrome P450 model reactions

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dc.contributor.authorNam, Won Woo-
dc.contributor.authorRyu, Yon Ok-
dc.contributor.authorSong, Woon Ju-
dc.date.accessioned2024-05-20T06:15:47Z-
dc.date.available2024-05-20T06:15:47Z-
dc.date.created2024-05-20-
dc.date.created2024-05-20-
dc.date.issued2004-09-
dc.identifier.citationJournal of Biological Inorganic Chemistry, Vol.9 No.6, pp.654-660-
dc.identifier.issn0949-8257-
dc.identifier.urihttps://hdl.handle.net/10371/203506-
dc.description.abstractOxoiron(IV) porphyrin pi-cation radicals have been considered as the sole reactive species in the catalytic oxidation of organic substrates by cytochromes P450 and their iron porphyrin models over the past two decades. Recent studies from several laboratories, however, have provided experimental evidence that multiple oxidizing species are involved in the oxygen transfer reactions and that the mechanism of oxygen transfer is much more complex than initially believed. In this Commentary, reactive intermediates that have been shown or proposed to be involved in iron porphyrin complex-catalyzed oxidation reactions are reviewed. Particularly, the current controversy on the oxoiron(IV) porphyrin pi-cation radical as a sole reactive species versus the involvement of multiple oxidizing species in oxygen transfer reactions is discussed.-
dc.language영어-
dc.publisherSpringer Verlag-
dc.titleOxidizing intermediates in cytochrome P450 model reactions-
dc.typeArticle-
dc.identifier.doi10.1007/s00775-004-0577-5-
dc.citation.journaltitleJournal of Biological Inorganic Chemistry-
dc.identifier.wosid000223956600003-
dc.identifier.scopusid2-s2.0-4644273736-
dc.citation.endpage660-
dc.citation.number6-
dc.citation.startpage654-
dc.citation.volume9-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorSong, Woon Ju-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusIRON(III) PORPHYRIN COMPLEX-
dc.subject.keywordPlusMULTIPLE ACTIVE OXIDANTS-
dc.subject.keywordPlusCOMPOUND-I FORMATION-
dc.subject.keywordPlusALIPHATIC HYDROXYLATION-
dc.subject.keywordPlusIRON PORPHYRINS-
dc.subject.keywordPlusOXYGEN-TRANSFER-
dc.subject.keywordPlusMN-III(SALEN)-CATALYZED EPOXIDATION-
dc.subject.keywordPlusELECTROPHILIC OXIDANTS-
dc.subject.keywordPlusMECHANISTIC PROBES-
dc.subject.keywordPlusHYDROPEROXO-IRON-
dc.subject.keywordAuthorcompound I-
dc.subject.keywordAuthorcytochrome P450-
dc.subject.keywordAuthoriron porphyrin-
dc.subject.keywordAuthormultiple oxidants-
dc.subject.keywordAuthoroxidation-
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  • College of Natural Sciences
  • Department of Chemistry
Research Area Biochemistry, Inorganic, 무기화학, 생화학

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