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Non-alcoholic fatty liver disease across the spectrum of hypothyroidism
DC Field | Value | Language |
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dc.contributor.author | Chung, Goh Eun | - |
dc.contributor.author | Kim, Donghee | - |
dc.contributor.author | Kim, Won | - |
dc.contributor.author | Yim, Jeong Yoon | - |
dc.contributor.author | Park, Min Jung | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.date.accessioned | 2024-05-29T01:30:24Z | - |
dc.date.available | 2024-05-29T01:30:24Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | Journal of Hepatology, Vol.57 No.1, pp.150-156 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203919 | - |
dc.description.abstract | Background & Aims: The aim of this study was to characterize the relationship between the broad spectrum of hypothyroidism and NAFLD. Methods: A cross-sectional study with 4648 health check-up subjects (2324 cases with hypothyroidism vs. age- and sex-matched controls) was conducted. The subjects were categorized as having either subclinical [thyroid-stimulating hormone (TSH) >= 4.1 mIU/L and normal free thyroixine (T-4) level (0.7-1.8 ng/dl)] or overt hypothyroidism [free T-4 < 0.7 ng/dl]. NAFLD was diagnosed on the basis of typical ultrasonographic findings, and alcohol consumption of less than 20 g/day in the absence of other causes of liver disease. Results: The mean age of the subjects was 48.6 +/- 11.8 years and 62.4% were female. NAFLD was significantly associated with hypothyroidism (30.2% patients vs. 19.5% control, p<0.001). The prevalence of NAFLD and abnormal liver enzyme levels (ALT > 33/25 IU/L) increased steadily with increasing grades of hypothyroidism (for NAFLD, subclinical: 29.9% and overt: 36.3%; for abnormal ALT, 20.1% and 25.9%, p < 0.001, respectively). Multivariate regression analysis showed that NAFLD was statistically significantly associated with hypothyroidism (odds ratio (OR) 1.38, 95% confidence interval (CI), 1.17-1.62) and the grade of hypothyroidism in a dose-dependent manner (OR 1.36, 95% CI, 1.16-1.61 in subclinical hypothyroidism and OR 1.71, 95% CI, 1.10-2.66 in overt hypothyroidism). Conclusions: Subclinical hypothyroidism, even in the range of upper normal TSH levels, was found to be related to NAFLD in a dose-dependent manner. Hypothyroidism is closely associated with NAFLD independently of known metabolic risk factors, confirming a relevant clinical relationship between these two diseases. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Non-alcoholic fatty liver disease across the spectrum of hypothyroidism | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jhep.2012.02.027 | - |
dc.citation.journaltitle | Journal of Hepatology | - |
dc.identifier.wosid | 000305811300022 | - |
dc.identifier.scopusid | 2-s2.0-84862704765 | - |
dc.citation.endpage | 156 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 150 | - |
dc.citation.volume | 57 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Jun | - |
dc.contributor.affiliatedAuthor | Yoon, Jung-Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Hyo-Suk | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | ALANINE AMINOTRANSFERASE | - |
dc.subject.keywordPlus | SUBCLINICAL HYPOTHYROIDISM | - |
dc.subject.keywordPlus | FREE T4 | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | TSH | - |
dc.subject.keywordAuthor | Hypothyroidism | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Metabolic syndrome | - |
dc.subject.keywordAuthor | Hepatic steatosis | - |
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