Publications

Detailed Information

Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-κB pathway : Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-kappa B pathway

Cited 63 time in Web of Science Cited 69 time in Scopus
Authors

Kwon, Woon Yong; Suh, Gil Joon; Kim, Kyung Su; Kwak, Young Ho

Issue Date
2011-02
Publisher
Lippincott Williams & Wilkins Ltd.
Citation
Critical Care Medicine, Vol.39 No.2, pp.328-334
Abstract
Objectives: To examine whether niacin attenuates lung inflammation and improves survival during sepsis and to determine whether the beneficial effects of niacin are associated with down-regulation of the nuclear factor (NF)-kappa B pathway. Design: Prospective laboratory study. Setting: University laboratory. Subjects: Male Sprague-Dawley rats (n = 119). Interventions: To induce endotoxemia in rats, lipopolysaccharide (Escherichia coli, O26:B6) at a dosage of 10 mg/kg was injected into a tail vein and 10 mins later, vehicle, a low dose of niacin (360 mg/kg), or a high dose of niacin (1180 mg/kg) was administered once through an orogastric tube, respectively. Measurements and Main Results: We observed the survival of the subjects for 72 hrs. At 6 hrs postlipopolysaccharide, we euthanized animals and measured cytoplasmic phosphorylated inhibitor kappa B-alpha and inhibitor kappa B-alpha expressions, nuclear NF-kappa B p65 expression, NF-kappa B p65 DNA-binding activity, tumor necrosis factor-alpha, and interleukin-6 gene expressions and histologic damages in lung tissues. We also measured nicotinamide adenine dinucleotide, reduced nicotinamide adenine dinucleotide phosphate, reduced glutathione, and malondialdehyde levels in lung tissues. High dose of niacin suppressed NF-kappa B activation and proinflammatory cytokine gene expressions in lung tissues, reduced histologic lung damages, and improved survival in endotoxemic rats. Furthermore, it increased nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and glutathione levels and decreased malondialdehyde level in lung tissues. Conclusions: High dose of niacin attenuated lung inflammation, reduced histologic lung damages, and improved survival during sepsis in rats. These therapeutic benefits were associated with downregulation of the NF-kappa B pathway. (Crit Care Med 2011; 39: 328-334)
ISSN
0090-3493
URI
https://hdl.handle.net/10371/203948
DOI
https://doi.org/10.1097/CCM.0b013e3181feeae4
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share