Publications
Detailed Information
Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Woon Yong | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kim, Kyung Su | - |
dc.contributor.author | Jo, You Hwan | - |
dc.contributor.author | Lee, Jae Hyuk | - |
dc.contributor.author | Kim, Kyuseok | - |
dc.contributor.author | Jung, Sung Koo | - |
dc.date.accessioned | 2024-05-29T01:38:16Z | - |
dc.date.available | 2024-05-29T01:38:16Z | - |
dc.date.created | 2021-12-21 | - |
dc.date.issued | 2010-03 | - |
dc.identifier.citation | British Journal of Nutrition, Vol.103 No.6, pp.890-898 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://hdl.handle.net/10371/203969 | - |
dc.description.abstract | Heat shock protein 70 (HSP70) is reported as the main factor responsible for the beneficial effects of glutamine (GLN) and as a negative regulator of high mobility group box protein-1 (HMGB-1) expression. Our aim was to determine whether GLN attenuates acute lung injury (ALI) by the inhibition of HMGB-1 expression during sepsis. Male Sprague Dawley rats were subjected to caecal ligation and puncture (CLP) to induce sepsis. GLN or saline was administered through tail vein 1 h after CLP. Then, quercetin (Q), an inhibitor of HSP70, was utilised to assess the role of the enhanced HSP70. We observed the survival of the subjects. At 24h post-CLP, we measured lung HSP70, phosphorylated heat shock factor-1 (HSF-1-p) and HMGB-1 expressions, NF-kappa B DNA-binding activity and ALI occurrence. We also measured serum HSP70, IL-6 and HMGB-1 concentrations. GLN improved survival during sepsis. In GLN-treated rats, lung HSP70 and HSF-1-p expressions were enhanced, lung HMGB-1 expression and NF-kappa B DNA-binding activity were suppressed, and ALI was attenuated. Furthermore, in GLN-administered rats, serum HSP70 concentration was higher, and serum IL-6 and HMGB-1 concentrations were lower than those in non-treated rats. Q inhibited the enhancement of HSP70 and HSF-1-p expressions and abrogated the GLN-mediated benefits. In conclusion, GLN attenuated ALI and improved survival by the inhibition of HMGB-1 expression during sepsis in rats. These benefits were associated with the enhancement of HSP70 expression by GLN. | - |
dc.language | 영어 | - |
dc.publisher | CABI Publishing | - |
dc.title | Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1017/S0007114509992509 | - |
dc.citation.journaltitle | British Journal of Nutrition | - |
dc.identifier.wosid | 000276230900014 | - |
dc.identifier.scopusid | 2-s2.0-77950344552 | - |
dc.citation.endpage | 898 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 890 | - |
dc.citation.volume | 103 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kwon, Woon Yong | - |
dc.contributor.affiliatedAuthor | Suh, Gil Joon | - |
dc.contributor.affiliatedAuthor | Jo, You Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Kyuseok | - |
dc.contributor.affiliatedAuthor | Jung, Sung Koo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HEAT-SHOCK-PROTEIN | - |
dc.subject.keywordPlus | HIGH-MOBILITY-GROUP-BOX-1 RELEASE | - |
dc.subject.keywordPlus | HEAT-SHOCK-PROTEIN-72 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | HMGB1 | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | Glutamine | - |
dc.subject.keywordAuthor | High mobility group box protein-1 | - |
dc.subject.keywordAuthor | Lung injury | - |
dc.subject.keywordAuthor | Sepsis | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.