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Glutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis

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dc.contributor.authorKwon, Woon Yong-
dc.contributor.authorSuh, Gil Joon-
dc.contributor.authorKim, Kyung Su-
dc.contributor.authorJo, You Hwan-
dc.contributor.authorLee, Jae Hyuk-
dc.contributor.authorKim, Kyuseok-
dc.contributor.authorJung, Sung Koo-
dc.date.accessioned2024-05-29T01:38:16Z-
dc.date.available2024-05-29T01:38:16Z-
dc.date.created2021-12-21-
dc.date.issued2010-03-
dc.identifier.citationBritish Journal of Nutrition, Vol.103 No.6, pp.890-898-
dc.identifier.issn0007-1145-
dc.identifier.urihttps://hdl.handle.net/10371/203969-
dc.description.abstractHeat shock protein 70 (HSP70) is reported as the main factor responsible for the beneficial effects of glutamine (GLN) and as a negative regulator of high mobility group box protein-1 (HMGB-1) expression. Our aim was to determine whether GLN attenuates acute lung injury (ALI) by the inhibition of HMGB-1 expression during sepsis. Male Sprague Dawley rats were subjected to caecal ligation and puncture (CLP) to induce sepsis. GLN or saline was administered through tail vein 1 h after CLP. Then, quercetin (Q), an inhibitor of HSP70, was utilised to assess the role of the enhanced HSP70. We observed the survival of the subjects. At 24h post-CLP, we measured lung HSP70, phosphorylated heat shock factor-1 (HSF-1-p) and HMGB-1 expressions, NF-kappa B DNA-binding activity and ALI occurrence. We also measured serum HSP70, IL-6 and HMGB-1 concentrations. GLN improved survival during sepsis. In GLN-treated rats, lung HSP70 and HSF-1-p expressions were enhanced, lung HMGB-1 expression and NF-kappa B DNA-binding activity were suppressed, and ALI was attenuated. Furthermore, in GLN-administered rats, serum HSP70 concentration was higher, and serum IL-6 and HMGB-1 concentrations were lower than those in non-treated rats. Q inhibited the enhancement of HSP70 and HSF-1-p expressions and abrogated the GLN-mediated benefits. In conclusion, GLN attenuated ALI and improved survival by the inhibition of HMGB-1 expression during sepsis in rats. These benefits were associated with the enhancement of HSP70 expression by GLN.-
dc.language영어-
dc.publisherCABI Publishing-
dc.titleGlutamine attenuates acute lung injury by inhibition of high mobility group box protein-1 expression during sepsis-
dc.typeArticle-
dc.identifier.doi10.1017/S0007114509992509-
dc.citation.journaltitleBritish Journal of Nutrition-
dc.identifier.wosid000276230900014-
dc.identifier.scopusid2-s2.0-77950344552-
dc.citation.endpage898-
dc.citation.number6-
dc.citation.startpage890-
dc.citation.volume103-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKwon, Woon Yong-
dc.contributor.affiliatedAuthorSuh, Gil Joon-
dc.contributor.affiliatedAuthorJo, You Hwan-
dc.contributor.affiliatedAuthorKim, Kyuseok-
dc.contributor.affiliatedAuthorJung, Sung Koo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusHEAT-SHOCK-PROTEIN-
dc.subject.keywordPlusHIGH-MOBILITY-GROUP-BOX-1 RELEASE-
dc.subject.keywordPlusHEAT-SHOCK-PROTEIN-72-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusHMGB1-
dc.subject.keywordPlusSTRESS-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusTRANSLOCATION-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordAuthorGlutamine-
dc.subject.keywordAuthorHigh mobility group box protein-1-
dc.subject.keywordAuthorLung injury-
dc.subject.keywordAuthorSepsis-
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