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The activin/BMP-2 chimera AB204 promotes periodontal tissue regeneration in a buccal dehiscence model: a pilot study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Hee-seung | - |
dc.contributor.author | Lee, Jung-Tae | - |
dc.contributor.author | Cho, Young-Dan | - |
dc.contributor.author | Kim, Sungtae | - |
dc.date.accessioned | 2024-07-12T01:56:20Z | - |
dc.date.available | 2024-07-12T01:56:20Z | - |
dc.date.created | 2024-06-04 | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Journal of Periodontal and Implant Science, Vol.54 No.3 | - |
dc.identifier.issn | 2093-2278 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204616 | - |
dc.description.abstract | Purpose: A combination of activin and bone morphogenetic protein-2 (BMP-2), termed AB204, has been shown to improve osteogenic potential with fewer side effects than BMP-2 alone. This study was performed to evaluate the effect of AB204 on periodontal tissue regeneration in a dog buccal dehiscence model. Methods: Buccal dehiscence defects were created on the maxillary premolars (P1, P2, and P3) of 6 mongrel dogs. After 5 weeks, the dogs were randomly assigned to 1 of 3 groups: the control, collagen matrix (CM), and CM/AB204 groups. Grafting procedures were then performed. The dogs were sacrificed 8 weeks after the grafting procedure, and volumetric and histological analyses were conducted. Results: The thickness of the buccal gingiva in the CM/AB204 group was greater than those in the other groups at 2 weeks (P<0.05). The ridge width in the AB204/CM group exceeded the width in the other groups at 4 and 8 weeks; however, the difference was not statistically significant. Histological analysis revealed that the CM/AB204 group demonstrated the formation of new bone surrounded by newly formed periodontal ligament and cementum (P=0.035). Conclusions: The combined application of CM and AB204 shows promise in facilitating the regeneration of periodontal attachment, including the formation of new bone, cementum, and periodontal ligament. | - |
dc.publisher | Korean Academy of Periodontology | - |
dc.title | The activin/BMP-2 chimera AB204 promotes periodontal tissue regeneration in a buccal dehiscence model: a pilot study | - |
dc.type | Article | - |
dc.identifier.doi | 10.5051/JPIS.2303600180 | - |
dc.citation.journaltitle | Journal of Periodontal and Implant Science | - |
dc.identifier.scopusid | 2-s2.0-85193804887 | - |
dc.citation.number | 3 | - |
dc.citation.volume | 54 | - |
dc.contributor.affiliatedAuthor | Cho, Young-Dan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | AB204 | - |
dc.subject.keywordAuthor | Activin | - |
dc.subject.keywordAuthor | Animal experimentation | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Collagen | - |
dc.subject.keywordAuthor | Dental cementum | - |
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