Publications

Detailed Information

Microbiota Association and Profiling of Gingival Sulci and Root Canals of Teeth with Primary or Secondary/Persistent Endodontic Infections

DC Field Value Language
dc.contributor.authorPark, Dong Hyun-
dc.contributor.authorPark, Ok-Jin-
dc.contributor.authorYoo, Yeon-Jee-
dc.contributor.authorPerinpanayagam, Hiran-
dc.contributor.authorCho, Eun-Bee-
dc.contributor.authorKim, Kwangmin-
dc.contributor.authorPark, Junhyung-
dc.contributor.authorNoblett, W. Craig-
dc.contributor.authorKum, Kee-Yeon-
dc.contributor.authorHan, Seung Hyun-
dc.date.accessioned2024-07-24T01:07:11Z-
dc.date.available2024-07-24T01:07:11Z-
dc.date.created2024-07-10-
dc.date.created2024-07-10-
dc.date.created2024-07-10-
dc.date.issued2024-08-
dc.identifier.citationJournal of Endodontics, Vol.50 No.8, pp.1124-1133-
dc.identifier.issn0099-2399-
dc.identifier.urihttps://hdl.handle.net/10371/204809-
dc.description.abstractIntroduction: Microbiota associated with primary endodontic infection (PEI) and secondary/persistent endodontic infection (SPEI) must be characterized to elucidate pathogenesis in apical periodontitis and bacterial biomarkers identified for diagnostic and therapeutic applications. Methods: This study analyzed the microbial community profiles of root canals and gingival sulci (sulcus-E) for teeth with PEI (n = 10) or SPEI (n = 10), using the Illumina MiSeq platform. Bacterial samples from gingival sulci (sulcus-C) of healthy contralateral teeth served as controls. Results: There were 15 phyla, 177 genera, and 340 species identified. The number and diversity of bacteria in root canals did not differ significantly between PEI and SPEI. Proteobacteria, Firmicutes, Fusobacteria, Bacteroidetes, and Actinobacteria were the dominant phyla in both groups. At the genus level, Lancefieldella, Bifidobacterium, Stomatobaculum, and Schaalia were enriched in root canals with SPEI. Of significance, Lancefieldella was observed in both root canals and sulcus-E of teeth with SPEI. At the species level, Neisseria macacae, Streptococcus gordonii, Bifidobacterium dentium, Stomatobaculum longum, and Schaalia odontolytica were increased significantly in root canals with SPEI compared to PEI. Oribacterium species, Streptococcus salivarius, Lancefieldella parvula, Prevotella denticola, and Oribacterium asaccharolyticum were more abundant in sulcus-E of teeth with SPEI compared to PEI. Conclusions: There were distinctive and differing predominant bacterial species associated with the root canals and gingival sulci between teeth with PEI and SPEI. Specific bacteria identified in sulcus-E and root canals of teeth with SPEI could serve as noninvasive diagnostic biomarkers for detecting SPEI.-
dc.language영어-
dc.publisherElsevier Inc.-
dc.titleMicrobiota Association and Profiling of Gingival Sulci and Root Canals of Teeth with Primary or Secondary/Persistent Endodontic Infections-
dc.typeArticle-
dc.identifier.doi10.1016/j.joen.2024.04.016-
dc.citation.journaltitleJournal of Endodontics-
dc.identifier.wosid001301296500001-
dc.identifier.scopusid2-s2.0-85195545999-
dc.citation.endpage1133-
dc.citation.number8-
dc.citation.startpage1124-
dc.citation.volume50-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKum, Kee-Yeon-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusPYROSEQUENCING ANALYSIS-
dc.subject.keywordPlusAPICAL PERIODONTITIS-
dc.subject.keywordPlusLESIONS-
dc.subject.keywordPlusFLORA-
dc.subject.keywordAuthorGingival sulcus-
dc.subject.keywordAuthorIllumina MiSeq platform sequencing-
dc.subject.keywordAuthormicrobiome-
dc.subject.keywordAuthornoninvasive diagnostic biomarker-
dc.subject.keywordAuthorprimary endodontic infection-
dc.subject.keywordAuthorsecondary/persistent endodontic infection-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share