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Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jung Ah | - |
dc.contributor.author | Kim, Sung -Hee | - |
dc.contributor.author | Kim, Jeong Jin | - |
dc.contributor.author | Noh, Hyuna | - |
dc.contributor.author | Lee, Su -bin | - |
dc.contributor.author | Jeong, Haengdueng | - |
dc.contributor.author | Kim, Jiseon | - |
dc.contributor.author | Jeon, Donghun | - |
dc.contributor.author | Seo, Jung Seon | - |
dc.contributor.author | On, Dain | - |
dc.contributor.author | Yoon, Suhyeon | - |
dc.contributor.author | Lee, Sang Gyu | - |
dc.contributor.author | Lee, Youn Woo | - |
dc.contributor.author | Jang, Hui Jeong | - |
dc.contributor.author | Park, In Ho | - |
dc.contributor.author | Oh, Jooyeon | - |
dc.contributor.author | Seok, Sang-Hyuk | - |
dc.contributor.author | Lee, Yu Jin | - |
dc.contributor.author | Hong, Seung-Min | - |
dc.contributor.author | An, Se -Hee | - |
dc.contributor.author | Bae, Joon -Yong | - |
dc.contributor.author | Choi, Jung-ah | - |
dc.contributor.author | Kim, Young Been | - |
dc.contributor.author | Hwang, Ji-Yeon | - |
dc.contributor.author | Lee, Hyo-Jung | - |
dc.contributor.author | Bin Kim, Hong | - |
dc.contributor.author | Jeong, Dae Gwin | - |
dc.contributor.author | Song, Daesub | - |
dc.contributor.author | Song, Manki | - |
dc.contributor.author | Park, Man-Seong | - |
dc.contributor.author | Choi, Kang-Seuk | - |
dc.contributor.author | Park, Jun Won | - |
dc.contributor.author | Yun, Jun -Won | - |
dc.contributor.author | Shin, Jeon-Soo | - |
dc.contributor.author | Lee, Ho -Young | - |
dc.contributor.author | Kwon, Ho-Keun | - |
dc.contributor.author | Seo, Jun-Young | - |
dc.contributor.author | Nam, Ki Taek | - |
dc.contributor.author | Gee, Heon Yung | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.date.accessioned | 2024-08-08T01:17:28Z | - |
dc.date.available | 2024-08-08T01:17:28Z | - |
dc.date.created | 2024-06-10 | - |
dc.date.created | 2024-06-10 | - |
dc.date.issued | 2024-04 | - |
dc.identifier.citation | Immune Network, Vol.24 No.2, p. e7 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204949 | - |
dc.description.abstract | Viral load and the duration of viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants of the transmission of coronavirus disease 2019. In this study, we examined the effects of viral doses on the lung and spleen of K18-hACE2 transgenic mice by temporal histological and transcriptional analyses. Approximately, 1x10 5 plaque -forming units (PFU) of SARS-CoV-2 induced strong host responses in the lungs from 2 days post inoculation (dpi) which did not recover until the mice died, whereas responses to the virus were obvious at 5 days, recovering to the basal state by 14 dpi at 1x10 2 PFU. Further, flow cytometry showed that number of CD8+ T cells continuously increased in 1x10 2 PFU-virusinfected lungs from 2 dpi, but not in 1x10 5 PFU-virus-infected lungs. In spleens, responses to the virus were prominent from 2 dpi, and number of B cells was significantly decreased at 1x10 5 PFU; however, 1x10 2 PFU of virus induced very weak responses from 2 dpi which recovered by 10 dpi. Although the defense responses returned to normal and the mice survived, lung histology showed evidence of fibrosis, suggesting sequelae of SARS-CoV-2 infection. Our findings indicate that specific effectors of the immune response in the lung and spleen were either increased or depleted in response to doses of SARS-CoV-2. This study demonstrated that the response of local and systemic immune effectors to a viral infection varies with viral dose, which either exacerbates the severity of the infection or accelerates its elimination. | - |
dc.language | 영어 | - |
dc.publisher | 대한면역학회 | - |
dc.title | Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.4110/in.2024.24.e7 | - |
dc.citation.journaltitle | Immune Network | - |
dc.identifier.wosid | 001223210600004 | - |
dc.identifier.scopusid | 2-s2.0-85200028215 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | e7 | - |
dc.citation.volume | 24 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Hyo-Jung | - |
dc.contributor.affiliatedAuthor | Song, Daesub | - |
dc.contributor.affiliatedAuthor | Seong, Je Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | R PACKAGE | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | K18-hACE2 mice | - |
dc.subject.keywordAuthor | Dose-response relationship | - |
dc.subject.keywordAuthor | immunologic | - |
dc.subject.keywordAuthor | Transcriptome profiling | - |
dc.subject.keywordAuthor | Immune response | - |
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