Publications
Detailed Information
Mechano-modulation of T cells for cancer immunotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyun, Jeongeun | - |
dc.contributor.author | Kim, So Jung | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.contributor.author | Kim, Hae-Won | - |
dc.date.accessioned | 2024-08-08T01:17:37Z | - |
dc.date.available | 2024-08-08T01:17:37Z | - |
dc.date.created | 2023-04-19 | - |
dc.date.created | 2023-04-19 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | Biomaterials, Vol.297, p. 122101 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204981 | - |
dc.description.abstract | Immunotherapy, despite its promise for future anti-cancer approach, faces significant challenges, such as off-tumor side effects, innate or acquired resistance, and limited infiltration of immune cells into stiffened extracellular matrix (ECM). Recent studies have highlighted the importance of mechano-modulation/-activation of immune cells (mainly T cells) for effective caner immunotherapy. Immune cells are highly sensitive to the applied physical forces and matrix mechanics, and reciprocally shape the tumor microenvironment. Engineering T cells with tuned properties of materials (e.g., chemistry, topography, and stiffness) can improve their expansion and activation ex vivo, and their ability to mechano-sensing the tumor specific ECM in vivo where they perform cytotoxic effects. T cells can also be exploited to secrete enzymes that soften ECM, thus increasing tumor infiltration and cellular therapies. Furthermore, T cells, such as chimeric antigen receptor (CAR)-T cells, genomic engineered to be spatiotemporally controllable by physical stimuli (e.g., ultrasound, heat, or light), can mitigate adverse off-tumor effects. In this review, we communicate these recent cutting-edge endeavors devoted to mechano-modulating/-activating T cells for effective cancer immunotherapy, and discuss future prospects and challenges in this field. | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Mechano-modulation of T cells for cancer immunotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2023.122101 | - |
dc.citation.journaltitle | Biomaterials | - |
dc.identifier.wosid | 000975161900001 | - |
dc.identifier.scopusid | 2-s2.0-85151555504 | - |
dc.citation.startpage | 122101 | - |
dc.citation.volume | 297 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Sung-Dae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TGF-BETA INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TCR | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | IPILIMUMAB | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | MOTILITY | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordAuthor | Biophysical cues | - |
dc.subject.keywordAuthor | Immunotherapy | - |
dc.subject.keywordAuthor | Mechano-modulation | - |
dc.subject.keywordAuthor | T cells | - |
dc.subject.keywordAuthor | Tumor microenvironment | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.