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Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis

Cited 1 time in Web of Science Cited 1 time in Scopus
Authors

Lim, Jae-Sung; Lee, Keon-Joo; Kim, Beom Joon; Ryu, Wi-Sun; Chung, Jinyong; Gwak, Dong-Seok; Lee, Ji Sung; Kim, Seong-Eun; Ko, Eunvin; Lee, Juneyoung; Han, Moon-Ku; Smith, Eric E.; Kim, Dong-Eog; Bae, Hee-Joon

Issue Date
2023-12
Publisher
Wiley-Blackwell
Citation
Journal of the American Heart Association, Vol.12 No.23, p. e030515
Abstract
BACKGROUND: This study explored the risk factors, neuroimaging features, and prognostic implications of nonhypertensive white matter hyperintensity (WMH) in patients with acute ischemic stroke and transient ischemic attack. METHODS AND RESULTS: We included 2283 patients with hypertension and 1003 without from a pool of 10 602. Associations of moderate-to-severe WMH with known risk factors, functional outcome, and a composite of recurrent stroke, myocardial infarction, and all-cause mortality were evaluated. A subset of 351 patients without hypertension and age- and sex-matched pairs with hypertension and moderate-to-severe WMH was created for a detailed topographic examination of WMH, lacunes, and microbleeds. Approximately 35% of patients without hypertension and 65% of patients with hypertensive stroke exhibited moderate-to-severe WMH. WMH was associated with age, female sex, and previous stroke, irrespective of hypertension. In patients without hypertension, WMH was associated with initial systolic blood pressure and was more common in the anterior temporal region. In patients with hypertension, WMH was associated with small vessel occlusion as a stroke mechanism and was more frequent in the periventricular region near the posterior horn of the lateral ventricle. The higher prevalence of occipital microbleeds in patients without hypertension and deep subcortical lacunes in patients with hypertension were also observed. Associations of moderate-to-severe WMH with 3-month functional outcome and 1-year cumulative incidence of the composite outcome were significant (both P<0.01), although the latter lost significance after adjustments. The associations between WMH and outcomes were consistent across hypertensive status. CONCLUSIONS: One-third of patients without hypertension with stroke have moderate-to-severe WMH. The pathogenesis of WMH may differ between patients without and with hypertension, but its impact on outcome appears similar.
ISSN
2047-9980
URI
https://hdl.handle.net/10371/205159
DOI
https://doi.org/10.1161/JAHA.123.030515
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  • College of Medicine
  • Department of Medicine
Research Area 뇌경색, 뇌졸중, 혈관성 인지장애 및 치매

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