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Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2
DC Field | Value | Language |
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dc.contributor.author | Lim, Ho-Kyung | - |
dc.contributor.author | Kwon, Ik-Jae | - |
dc.contributor.author | On, Sung-Woon | - |
dc.contributor.author | Hong, Seok-Jin | - |
dc.contributor.author | Yang, Byoung-Eun | - |
dc.contributor.author | Kim, Soung-Min | - |
dc.contributor.author | Lee, Jong-Ho | - |
dc.contributor.author | Byun, Soo-Hwan | - |
dc.date.accessioned | 2024-08-08T01:23:16Z | - |
dc.date.available | 2024-08-08T01:23:16Z | - |
dc.date.created | 2021-12-06 | - |
dc.date.created | 2021-12-06 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.citation | International Journal of Molecular Sciences, Vol.22 No.21, p. 11485 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205599 | - |
dc.description.abstract | Our aim was to investigate the bone regeneration capacity of powder-type biphasic ceramic scaffold (BCP powder), block-type BCP (BCP block), and collagen-added block-type BCP (BCP collagen) with different concentrations of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an animal model. Four rabbits were assigned to each of the following groups: no graft + rhBMP-2 (0.1/0.2 mg/mL), BCP powder + rhBMP-2 (0.1/0.2 mg/mL), BCP block + rhBMP-2 (0.1/0.2 mg/mL), and BCP collagen + rhBMP-2 (0.1/0.2 mg/mL), i.e., a total of 32 rabbits. Polycarbonate tubes (phi 7 mm x 5 mm) for supporting scaffolds were fixed into a 7 mm round border. Subsequently, 0.1 mL of rhBMP-2 solutions with different concentrations was injected into the tubes. Both radiological and histomorphometric analyses showed that osteogenesis was not enhanced by increasing the concentration of rhBMP-2 in all groups at both 3 and 6 weeks. Radiological analysis showed that bone formation was higher in the BCP collagen group than in the BCP powder and BCP block groups at both rhBMP-2 concentrations at 3 weeks. rhBMP-2 enhanced bone formation; however, as the concentration increased, bone formation could not be enhanced infinitely. Collagen-added alloplastic graft material may be useful for mediating rapid bone formation in initial stages. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2 | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms222111485 | - |
dc.citation.journaltitle | International Journal of Molecular Sciences | - |
dc.identifier.wosid | 000723296700001 | - |
dc.identifier.scopusid | 2-s2.0-85117580744 | - |
dc.citation.number | 21 | - |
dc.citation.startpage | 11485 | - |
dc.citation.volume | 22 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Soung-Min | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BETA-TRICALCIUM PHOSPHATE | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO EVALUATION | - |
dc.subject.keywordPlus | CALCIUM-PHOSPHATE | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN | - |
dc.subject.keywordPlus | TRABECULAR BONE | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | POROSITY | - |
dc.subject.keywordPlus | CARRIER | - |
dc.subject.keywordPlus | GRAFTS | - |
dc.subject.keywordAuthor | biphasic calcium phosphate | - |
dc.subject.keywordAuthor | block-type biphasic calcium phosphate scaffold | - |
dc.subject.keywordAuthor | collagen | - |
dc.subject.keywordAuthor | recombinant human bone morphogenic protein 2 | - |
dc.subject.keywordAuthor | bone regeneration | - |
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