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Relation of Pre-Stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes
DC Field | Value | Language |
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dc.contributor.author | Ryu, Wi-Sun | - |
dc.contributor.author | Schellingerhout, Dawid | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Jeong, Sang-Wuk | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Kim, Joon-Tae | - |
dc.contributor.author | Lee, Kyung Bok | - |
dc.contributor.author | Park, Tai Hwan | - |
dc.contributor.author | Park, Sang-Soon | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kang, Kyusik | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Park, Hong-Kyun | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Oh, Mi Sun | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Kim, Jae Guk | - |
dc.contributor.author | Cha, Jae-Kwan | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.contributor.author | Park, Man Seok | - |
dc.contributor.author | Choi, Kang-Ho | - |
dc.contributor.author | Nahrendorf, Matthias | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.date.accessioned | 2024-08-08T01:23:18Z | - |
dc.date.available | 2024-08-08T01:23:18Z | - |
dc.date.created | 2021-11-05 | - |
dc.date.created | 2021-11-05 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.citation | Annals of Neurology, Vol.90 No.5, pp.763-776 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205604 | - |
dc.description.abstract | Objective: We investigated (1) the associations between pre-stroke aspirin use and thrombus burden, infarct volume, hemorrhagic transformation, early neurological deterioration (END), and functional outcome, and (2) whether stroke subtypes modify these associations in first-ever ischemic stroke. Methods: This multicenter magnetic resonance imaging (MRI)-based study included 5,700 consecutive patients with acute first-ever ischemic stroke, who did not undergo intravenous thrombolysis or endovascular thrombectomy, from May 2011 through February 2014. Propensity score-based augmented inverse probability weighting was performed to estimate adjusted effects of pre-stroke aspirin use. Results: The mean age was 67 years (41% women), and 15.9% (n = 907) were taking aspirin before stroke. Pre-stroke aspirin use (vs nonuse) was significantly related to a reduced infarct volume (by 30%), particularly in large artery atherosclerosis stroke (by 45%). In cardioembolic stroke, pre-stroke aspirin use was associated with a similar to 50% lower incidence of END (adjusted difference = -5.4%, 95% confidence interval [CI] = -8.9 to -1.9). Thus, pre-stroke aspirin use was associated with similar to 30% higher likelihood of favorable outcome (3-month modified Rankin Scale score < 3), particularly in large artery atherosclerosis stroke and cardioembolic stroke (adjusted difference = 7.2%, 95% CI = 1.8 to 12.5 and adjusted difference = 6.4%, 95% CI = 1.7 to 11.1, respectively). Pre-stroke aspirin use (vs nonuse) was associated with 85% less frequent cerebral thrombus-related susceptibility vessel sign (SVS) in large artery atherosclerosis stroke (adjusted difference = -1.4%, 95% CI = -2.1 to -0.8, p < 0.001) and was associated with similar to 40% lower SVS volumes, particularly in cardioembolic stroke (adjusted difference = -0.16 cm(3), 95% CI = -0.29 to -0.02, p = 0.03). Moreover, pre-stroke aspirin use was not significantly associated with hemorrhagic transformation (adjusted difference = -1.1%, p = 0.09). Interpretation :Pre-stroke aspirin use associates with improved functional independence in patients with first-ever ischemic large arterial stroke by reducing infarct volume and/or END, likely by decreasing thrombus burden, without increased risk of hemorrhagic transformation. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Relation of Pre-Stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ana.26219 | - |
dc.citation.journaltitle | Annals of Neurology | - |
dc.identifier.wosid | 000703626200001 | - |
dc.identifier.scopusid | 2-s2.0-85116381500 | - |
dc.citation.endpage | 776 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 763 | - |
dc.citation.volume | 90 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Bae, Hee-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | HEMORRHAGIC TRANSFORMATION | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | THROMBECTOMY | - |
dc.subject.keywordPlus | LEUKOARAIOSIS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | REGISTRY | - |
dc.subject.keywordPlus | SUBTYPE | - |
dc.subject.keywordPlus | GROWTH | - |
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