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Differential effects of body mass index on domain-specific cognitive outcomes after stroke
DC Field | Value | Language |
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dc.contributor.author | Lee, Minwoo | - |
dc.contributor.author | Oh, Mi Sun | - |
dc.contributor.author | Jung, San | - |
dc.contributor.author | Lee, Ju-Hun | - |
dc.contributor.author | Kim, Chul-Ho | - |
dc.contributor.author | Jang, Min Uk | - |
dc.contributor.author | Kim, Young Eun | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.contributor.author | Park, Jaeseol | - |
dc.contributor.author | Kang, Yeonwook | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Lim, Jae-Sung | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.date.accessioned | 2024-08-08T01:23:49Z | - |
dc.date.available | 2024-08-08T01:23:49Z | - |
dc.date.created | 2021-08-11 | - |
dc.date.created | 2021-08-11 | - |
dc.date.issued | 2021-07-08 | - |
dc.identifier.citation | Scientific Reports, Vol.11 No.1, p. 14168 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205684 | - |
dc.description.abstract | Although the obesity paradox is an important modifiable factor in cardiovascular diseases, little research has been conducted to determine how it affects post-stroke cognitive function. We aimed to investigate the association between body mass index (BMI) and domain-specific cognitive outcomes, focusing on the subdivision of each frontal domain function in post-ischemic stroke survivors. A total of 335 ischemic stroke patients were included in the study after completion of the Korean-Mini Mental Status Examination (K-MMSE) and the vascular cognitive impairment harmonization standards neuropsychological protocol at 3 months after stroke. Frontal lobe functions were analyzed using semantic/phonemic fluency, processing speed, and mental set shifting. Our study participants were categorized into four groups according to BMI quartiles. The z-scores of K-MMSE at 3 months differed significantly between the groups after adjustment for initial stroke severity (p=0.014). Global cognitive function in stroke survivors in the Q1 (the lowest quartile) BMI group was significantly lower than those in Q2 and Q4 (the highest quartile) BMI groups (K-MMSE z-scores, Q1:-2.10 +/- 3.40 vs. Q2: 0.71 +/- 1.95 and Q4:-1.21 +/- 1.65). Controlled oral word association test findings indicated that phonemic and semantic word fluency was lower in Q4 BMI group participants than in Q2 BMI group participants (p=0.016 and p=0.023 respectively). BMI might differentially affect cognitive domains after ischemic stroke. Although being underweight may negatively affect global cognition post-stroke, obesity could induce frontal lobe dysfunctions, specifically phonemic and semantic word fluency. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Differential effects of body mass index on domain-specific cognitive outcomes after stroke | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-021-93714-7 | - |
dc.citation.journaltitle | Scientific Reports | - |
dc.identifier.wosid | 000674513600086 | - |
dc.identifier.scopusid | 2-s2.0-85109703275 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 14168 | - |
dc.citation.volume | 11 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Bae, Hee-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OBESITY PARADOX | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | MIDLIFE | - |
dc.subject.keywordPlus | LEPTIN | - |
dc.subject.keywordPlus | AGE | - |
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