Publications

Detailed Information

BIOBANKING FOR GLOMERULAR DISEASES: A STUDY DESIGN AND PROTOCOL FOR KOREA RENAL BIOBANK NETWORK SYSTEM TOWARD NEXT-GENERATION ANALYSIS (KORNERSTONE)

DC Field Value Language
dc.contributor.authorKang, Eunjeong-
dc.contributor.authorKim, Yaerim-
dc.contributor.authorKim, Yong Chul-
dc.contributor.authorLee, Soojin-
dc.contributor.authorHan, Seungyeup-
dc.contributor.authorChoe, Minsun-
dc.contributor.authorHwang, Jin Ho-
dc.contributor.authorLee, Sunhwa-
dc.contributor.authorPark, Ji In-
dc.contributor.authorPark, Jung Tak-
dc.contributor.authorLim, Beom Jin-
dc.contributor.authorLee, Jung Pyo-
dc.contributor.authorAn, Jung Nam-
dc.contributor.authorRyu, Dong-Ryeol-
dc.contributor.authorKim, Jung-Hyun-
dc.contributor.authorKang, Hee Gyung-
dc.contributor.authorLee, Hyun Soon-
dc.contributor.authorMoon, Kyung Chul-
dc.contributor.authorJoo, Kwon Wook-
dc.contributor.authorKook-Hwan, Oh-
dc.contributor.authorHan, Seung Seok-
dc.contributor.authorLee, Hajeong-
dc.contributor.authorKim, Dong Ki-
dc.date.accessioned2024-08-08T01:26:44Z-
dc.date.available2024-08-08T01:26:44Z-
dc.date.created2024-03-19-
dc.date.created2024-03-19-
dc.date.issued2020-06-
dc.identifier.citationNephrology Dialysis Transplantation, Vol.35, pp.812-812-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://hdl.handle.net/10371/205962-
dc.description.abstractBackground and Aims
Glomerular diseases, a set of debilitating and complex disease entities, are related to mortality and morbidity. To gain insight into pathophysiology and novel treatment targets of glomerular disease, various types of biospecimens linked to deep clinical phenotyping including clinical information, digital pathology, and well-defined outcomes are required. We provide the rationale and design of the KOrea Renal biobank NEtwoRk System TOward Next-generation analysis (KORNERSTONE).

Method
The KORNERSTONE, which has been initiated by Korea Centres for Disease Control and Prevention, is designed as a multi-centre, prospective cohort study and biobank for glomerular diseases. Clinical data, questionnaires will be collected at the time of kidney biopsy and subsequently every one year after kidney biopsy. All of the clinical data will be extracted from the electrical health record and automatically uploaded to the web-based database. High-quality digital pathologies are obtained and connected in the database. Various types of biospecimens are collected at baseline and during follow-up: serum, urine, buffy coat, stool, glomerular complementary DNA (cDNA), tubulointerstitial cDNA. All data and biospecimens are processed and stored in a standardised manner. The primary outcomes are mortality and end-stage renal disease. The secondary outcomes will be deterioration renal function, remission of proteinuria, cardiovascular events and quality of life.

Disussion
Ethical approval has been obtained from the institutional review board of each participating centre and ethics oversight committee. The KORNERSTONE is designed to deliver pioneer insights into glomerular diseases. The study design allows comprehensive, integrated and high-quality data collection on baseline laboratory findings, clinical outcomes including administrative data and digital pathologic images. This may provide various biospecimens and information to many researchers, establish the rationale for future more individualised treatment strategies for glomerular diseases.

Conclusion
In conclusion, we describe the objectives and clinical protocol for the KORNERSTONE. As the first large-scale glomerulonephropathy cohort study with the integration of clinical data, biospecimens and digital pathologic images in Korea, the KORNERSTONE will help to clarify the natural course, complication profiles, and novel treatment targets of the Asian population with glomerular disease.
-
dc.language영어-
dc.publisherOxford University Press-
dc.titleBIOBANKING FOR GLOMERULAR DISEASES: A STUDY DESIGN AND PROTOCOL FOR KOREA RENAL BIOBANK NETWORK SYSTEM TOWARD NEXT-GENERATION ANALYSIS (KORNERSTONE)-
dc.typeArticle-
dc.identifier.doi10.1093/ndt/gfaa142.P0502-
dc.citation.journaltitleNephrology Dialysis Transplantation-
dc.identifier.wosid000562392101042-
dc.citation.endpage812-
dc.citation.startpage812-
dc.citation.volume35-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Yong Chul-
dc.contributor.affiliatedAuthorLee, Jung Pyo-
dc.contributor.affiliatedAuthorKang, Hee Gyung-
dc.contributor.affiliatedAuthorMoon, Kyung Chul-
dc.contributor.affiliatedAuthorJoo, Kwon Wook-
dc.contributor.affiliatedAuthorKook-Hwan, Oh-
dc.contributor.affiliatedAuthorKim, Dong Ki-
dc.type.docTypeMeeting Abstract-
dc.description.journalClass1-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

  • College of Medicine
  • Department of Medicine
Research Area Nephrology, Transplantation, Urology

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share