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FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Almansoori, Akram Abdo | - |
dc.contributor.author | Khentii, Namuun | - |
dc.contributor.author | Ju, Kyung Won | - |
dc.contributor.author | Kim, Bongju | - |
dc.contributor.author | Kim, Soung Min | - |
dc.contributor.author | Lee, Jong-Ho | - |
dc.date.accessioned | 2024-08-08T01:26:48Z | - |
dc.date.available | 2024-08-08T01:26:48Z | - |
dc.date.created | 2020-08-26 | - |
dc.date.created | 2020-08-26 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | 대한구강악안면외과학회지, Vol.46 No.3, pp.197-203 | - |
dc.identifier.issn | 2234-7550 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205974 | - |
dc.description.abstract | Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation. Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group) as follows: allograft rejection control (Allo-Ctrl), low dose (0.08 mg/kg) of FK506 (FK506-L), and high dose (0.16 mg/kg) of FK506 (FK506-H). Allograft survival and rejection were assessed by clinical observation, interleukin-2 levels as determined by enzyme-linked immunosorbent assay, blood sampling for complete blood count (CBC), and histological evaluation. Results: Body weight and anorexia were higher in the FK506-H group but without a significant difference compared with the FK506-L population. CBC revealed a non-significantly reduced number of changes in the FK506-L group. Four glands in the FK506-H group and two glands in the FK506-L group were viable and functioning post-transplantation. Conclusion: The survival rate of allotransplanted glands was higher in conjunction with the high dose of 0.16 mg/kg of FK506, with no major difference in the side-effect profile when compared with the low dose of 0.08 mg/kg short-term outcomes. | - |
dc.language | 영어 | - |
dc.publisher | 대한구강악안면외과학회 | - |
dc.title | FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit | - |
dc.type | Article | - |
dc.identifier.doi | 10.5125/jkaoms.2020.46.3.197 | - |
dc.citation.journaltitle | 대한구강악안면외과학회지 | - |
dc.identifier.wosid | 000545944900006 | - |
dc.identifier.scopusid | 2-s2.0-85090445561 | - |
dc.citation.endpage | 203 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 197 | - |
dc.citation.volume | 46 | - |
dc.identifier.kciid | ART002600082 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Soung Min | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FUNCTIONAL RECOVERY | - |
dc.subject.keywordPlus | TACROLIMUS | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordAuthor | Submandibular salivary gland | - |
dc.subject.keywordAuthor | Allotransplantation | - |
dc.subject.keywordAuthor | Immunosuppression | - |
dc.subject.keywordAuthor | FK506 | - |
dc.subject.keywordAuthor | Tacrolimus | - |
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