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Efficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After contrast-Enhanced Computed Tomography
DC Field | Value | Language |
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dc.contributor.author | Park, Sehoon | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.contributor.author | Jung, Hee-Yeon | - |
dc.contributor.author | Kim, Chan-Duck | - |
dc.contributor.author | Cho, Jang-Hee | - |
dc.contributor.author | Cha, Ran-hui | - |
dc.contributor.author | Jeong, Jong Cheol | - |
dc.contributor.author | Kim, Sejoong | - |
dc.contributor.author | Kim, Hyung-Jong | - |
dc.contributor.author | Ban, Tae Hyun | - |
dc.contributor.author | Ha Chung, Byung | - |
dc.contributor.author | Lee, Jung Pyo | - |
dc.contributor.author | Park, Jung Tak | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.contributor.author | Ryu, Dong-Ryeol | - |
dc.contributor.author | Moon, Sung Jin | - |
dc.contributor.author | Lee, Jung Eun | - |
dc.contributor.author | Huh, Wooseong | - |
dc.contributor.author | Kang, Ea Wha | - |
dc.contributor.author | Chang, Tae Ik | - |
dc.contributor.author | Joo, Kwon Wook | - |
dc.date.accessioned | 2024-08-08T01:27:05Z | - |
dc.date.available | 2024-08-08T01:27:05Z | - |
dc.date.created | 2021-10-06 | - |
dc.date.created | 2021-10-06 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.citation | Kidney Medicine, Vol.2 No.2, pp.189-195 | - |
dc.identifier.issn | 2590-0595 | - |
dc.identifier.uri | https://hdl.handle.net/10371/206025 | - |
dc.description.abstract | Rationale & Objective: We aimed to elucidate whether a balanced salt solution decreases the occurrence of contrast-induced acute kidney injury (CI-AKI) after contrast-enhanced computed tomography (CE-CT) as compared to 0.9% saline solution. Study Design: A randomized clinical trial. Setting & Participants: The study was performed in 14 tertiary hospitals in South Korea. Patients with estimated glomerular filtration rates (eGFRs) < 45 or <60 mL/min/1.73 m(2) and additional risk factors (age >= 60 years or diabetes) who were undergoing scheduled CE-CT were included from December 2016 to December 2018. Intervention: An open-label intervention was performed. The study group received a balanced salt solution and the control group received 0.9% saline solution as prophylactic fluids for CE-CT. Outcomes: The primary outcome was CI-AKI, defined by creatinine level elevation >= 0.5 mg/dL or 25% from baseline within 48 to 72 hours after CE-CT. Secondary outcomes included AKI defined based on the KDIGO (Kidney Disease: Improving Global Outcomes) guideline, eGFR changes, death, or requiring dialysis within 6 months after CE-CT. Results: 493 patients received the study fluids. The control and study groups included 251 and 242 patients, respectively. The occurrence of CI-AKI in the study (10 [4.2%]) and control (17 [6.8%]) groups was not significantly different (P= 0.27). No significant difference was present for the secondary outcomes; AKI by the KDIGO definition (study: 19 [7.9%], control: 27 [10.8%]; P = 0.33), death/dialysis (study: 11 [4.7%], control: 9 [3.7%]; P = 0.74), and eGFR changes (study: 0.1 +/- 0.2 mg/dL, control: 0.3 +/- 2.8 mg/dL; P = 0.69). Limitations: This study failed to meet target enrollment. Conclusions: The risk for CI-AKI was similar after administration of a balanced salt solution and after use of 0.9% saline solution during CE-CT in higher-risk patients. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Efficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After contrast-Enhanced Computed Tomography | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.xkme.2019.12.003 | - |
dc.citation.journaltitle | Kidney Medicine | - |
dc.identifier.wosid | 000659969900013 | - |
dc.identifier.scopusid | 2-s2.0-85082800782 | - |
dc.citation.endpage | 195 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 189 | - |
dc.citation.volume | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ki | - |
dc.contributor.affiliatedAuthor | Lee, Jung Pyo | - |
dc.contributor.affiliatedAuthor | Joo, Kwon Wook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CORTICAL TISSUE PERFUSION | - |
dc.subject.keywordPlus | DOUBLE-BLIND CROSSOVER | - |
dc.subject.keywordPlus | BLOOD-FLOW-VELOCITY | - |
dc.subject.keywordPlus | CORONARY-ANGIOGRAPHY | - |
dc.subject.keywordPlus | INDUCED NEPHROPATHY | - |
dc.subject.keywordPlus | SODIUM-BICARBONATE | - |
dc.subject.keywordPlus | CHLORIDE | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | acute renal failure | - |
dc.subject.keywordAuthor | balanced salt solution | - |
dc.subject.keywordAuthor | computed tomography | - |
dc.subject.keywordAuthor | Contrast-induced acute kidney injury | - |
dc.subject.keywordAuthor | fluid | - |
dc.subject.keywordAuthor | saline | - |
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