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Multidrug-resistant tuberculosis over 20 years at a referral hospital in South Korea: trends and outcomes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwak, N. | - |
dc.contributor.author | Kim, H-R. | - |
dc.contributor.author | Yoo, C-G. | - |
dc.contributor.author | Kim, Y. W. | - |
dc.contributor.author | Han, S. K. | - |
dc.contributor.author | Yim, J-J. | - |
dc.date.accessioned | 2024-08-08T01:30:08Z | - |
dc.date.available | 2024-08-08T01:30:08Z | - |
dc.date.created | 2020-04-16 | - |
dc.date.created | 2020-04-16 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.citation | International Journal of Tuberculosis and Lung Disease, Vol.23 No.2, pp.174-180 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.uri | https://hdl.handle.net/10371/206303 | - |
dc.description.abstract | SETTING: A referral centre in South Korea. OBJECTIVE : To investigate trends in drug resistance, treatment modalities and outcomes, and adverse events of multidrug-resistant tuberculosis (MDR-TB) over two decades. DESIGN: MDR-TB patients treated at Seoul National Hospital University between 1996 and 2015 were divided into four 5-year cohorts according to the date of initial diagnosis. Changes in demographic characteristics, drug resistance, drugs used, treatment outcomes and adverse events over time were elucidated. RESULTS: Between 1996 and 2015, 418 patients were treated for MDR-TB: 86 patients between 1996 and 2000, 125 between 2001 and 2005, 123 between 2006 and 2010, and 84 between 2011 and 2015. The proportion of patients with positive acid-fast bacilli sputum (60.5-29.7%, P < 001) or cavities on chest radiographs (86.0-40.5%, P < 001) decreased over time. Resistance to pyrazinamide, fluoroquinolones, cycloserine and p-aminosalicylic acid decreased. Later-generation fluoroquinolones (77.9-90.5%) and linezolid (0-26.2%) became more frequently prescribed. The treatment success rate increased (45.3-88.1%, P < 0.001); neurological adverse events, including peripheral neuropathy also increased (4.7-13.1%, P = 0.027). CONCLUSION: MDR-TB patients presented with less severe disease and better resistance profiles over time in South Korea, with treatment outcomes improving continuously. | - |
dc.language | 영어 | - |
dc.publisher | International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories | - |
dc.title | Multidrug-resistant tuberculosis over 20 years at a referral hospital in South Korea: trends and outcomes | - |
dc.type | Article | - |
dc.identifier.doi | 10.5588/ijtld.18.0295 | - |
dc.citation.journaltitle | International Journal of Tuberculosis and Lung Disease | - |
dc.identifier.wosid | 000459791400010 | - |
dc.identifier.scopusid | 2-s2.0-85065427998 | - |
dc.citation.endpage | 180 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 174 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yim, J-J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ADVERSE DRUG-REACTIONS | - |
dc.subject.keywordPlus | NUTRITIONAL DEFICIT | - |
dc.subject.keywordPlus | CULTURE CONVERSION | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | DEFINITIONS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | TB | - |
dc.subject.keywordAuthor | fluoroquinolone | - |
dc.subject.keywordAuthor | linezolid | - |
dc.subject.keywordAuthor | bedaquiline | - |
dc.subject.keywordAuthor | delamanid | - |
dc.subject.keywordAuthor | surgery | - |
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