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Recombinant human fibroblast growth factor-2 promotes nerve regeneration and functional recovery after mental nerve crush injury
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Ho | - |
dc.contributor.author | Jin, Wei-Peng | - |
dc.contributor.author | Seo, Na Ri | - |
dc.contributor.author | Pang, Kang-Mi | - |
dc.contributor.author | Kim, Bongju | - |
dc.contributor.author | Kim, Soung-Min | - |
dc.contributor.author | Lee, Jong Ho | - |
dc.date.accessioned | 2024-08-08T01:34:01Z | - |
dc.date.available | 2024-08-08T01:34:01Z | - |
dc.date.created | 2018-08-22 | - |
dc.date.created | 2018-08-22 | - |
dc.date.issued | 2017-04 | - |
dc.identifier.citation | Neural Regeneration Research, Vol.12 No.4, pp.629-636 | - |
dc.identifier.issn | 1673-5374 | - |
dc.identifier.uri | https://hdl.handle.net/10371/206731 | - |
dc.description.abstract | Several studies have shown that fibroblast growth factor-2 (FGF2) can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the effect of recombinant human FGF-2 (rhFGF2) treatment on damaged mental nerves. The mental nerves of 6-week-old male Sprague-Dawley rats were crush-injured for 1 minute and then treated with 10 or 50 mg/mL rhFGF2 or PBS in crush injury area with a mini Osmotic pump. Sensory test using von Frey filaments at 1 week revealed the presence of sensory degeneration based on decreased gap score and increased difference score. However, at 2 weeks, the gap score and difference score were significantly rebounded in the mental nerve crush group treated with 10 mg/mL rhFGF2. Interestingly, treatment with 10 mg/mL rhFGF had a more obviously positive effect on the gap score than treatment with 50 mg/mL rhFGF2. In addition, retrograde neuronal tracing with Dil revealed a significant increase in nerve regeneration in the trigeminal ganglion at 2 and 4 weeks in the rhFGF2 groups (10 mg/mL and 50 mg/mL) than in the PBS group. The 10 mg/mL rhFGF2 group also showed an obviously robust regeneration in axon density in the mental nerve at 4 weeks. Our results demonstrate that 10 mg/mL rhFGF induces mental nerve regeneration and sensory recovery after mental nerve crush injury. | - |
dc.language | 영어 | - |
dc.publisher | Neural Regeneration Research | - |
dc.title | Recombinant human fibroblast growth factor-2 promotes nerve regeneration and functional recovery after mental nerve crush injury | - |
dc.type | Article | - |
dc.identifier.doi | 10.4103/1673-5374.205104 | - |
dc.citation.journaltitle | Neural Regeneration Research | - |
dc.identifier.wosid | 000400920000027 | - |
dc.identifier.scopusid | 2-s2.0-85019087349 | - |
dc.citation.endpage | 636 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 629 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Soung-Min | - |
dc.contributor.affiliatedAuthor | Lee, Jong Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ADULT SENSORY NEURONS | - |
dc.subject.keywordPlus | RAT SCIATIC-NERVE | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | GENE-TRANSFER | - |
dc.subject.keywordPlus | FACTOR NGF | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ALLODYNIA | - |
dc.subject.keywordAuthor | nerve regeneration | - |
dc.subject.keywordAuthor | mental nerve | - |
dc.subject.keywordAuthor | fibroblast growth factor | - |
dc.subject.keywordAuthor | crush injury | - |
dc.subject.keywordAuthor | sensory neuron | - |
dc.subject.keywordAuthor | functional recovery | - |
dc.subject.keywordAuthor | neural regeneration | - |
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