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TPL2 Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jun-Han | - |
dc.contributor.author | Lee, Joo-Hyung | - |
dc.contributor.author | Lee, Sang Hyuk | - |
dc.contributor.author | Do, Sung-Im | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.contributor.author | Forslund, Ola | - |
dc.contributor.author | Inn, Kyung-Soo | - |
dc.contributor.author | Lee, Jeong-Sang | - |
dc.contributor.author | Deng, Fang-Ming | - |
dc.contributor.author | Melamed, Jonathan | - |
dc.contributor.author | Jung, Jae U. | - |
dc.contributor.author | Jeong, Joseph H. | - |
dc.date.accessioned | 2024-08-08T01:35:35Z | - |
dc.date.available | 2024-08-08T01:35:35Z | - |
dc.date.created | 2018-08-24 | - |
dc.date.created | 2018-08-24 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | Cancer Research, Vol.76 No.22, pp.6712-6722 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://hdl.handle.net/10371/206852 | - |
dc.description.abstract | Squamous cell carcinoma (SCC) and keratoacanthoma (KA; SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathologic features of human SCC/KA. Here, we show that TPL2 overexpression induced both cell transformation in immortalized human keratinocytes and SCC and KA-like cutaneous SCC (cSCC) development in mice. Mechanistically, activation of TPL2 downstream signaling pathways such as MEK/ERK MAPK, mTOR, NF-kB, and p38 MAPK leads to TPL2-mediated cell transformation in immortalized human keratinocytes and tumorigenesis in mice. Most importantly, TPL2 overexpression is required for iTPL2 TG-driven SCC and KA-like cSCC tumor maintenance, validating TPL2 as a possible drug target for the treatment of SCC/KA. Finally, we verified that TPL2 is overexpressed in human cutaneous metastatic SCC and KA clinical specimens compared with normal skin. Taken together, our results establish TPL2 as an oncogenic driver in SCC/KA development. | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research | - |
dc.title | TPL2 Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-15-3274 | - |
dc.citation.journaltitle | Cancer Research | - |
dc.identifier.wosid | 000388742100028 | - |
dc.identifier.scopusid | 2-s2.0-84995539023 | - |
dc.citation.endpage | 6722 | - |
dc.citation.number | 22 | - |
dc.citation.startpage | 6712 | - |
dc.citation.volume | 76 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Sung-Dae | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SKIN-CANCER | - |
dc.subject.keywordPlus | SERINE/THREONINE KINASE | - |
dc.subject.keywordPlus | P53 MUTATIONS | - |
dc.subject.keywordPlus | ACTIVATE ERK | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | INFLAMMATION | - |
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