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Comparison of the sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT.TB according to patient age
DC Field | Value | Language |
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dc.contributor.author | Bae, Won | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Song, Eun Young | - |
dc.contributor.author | Kim, Se Joong | - |
dc.contributor.author | Lee, Yeon Joo | - |
dc.contributor.author | Park, Jong Sun | - |
dc.contributor.author | Cho, Young-Jae | - |
dc.contributor.author | Yoon, Ho Il | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.contributor.author | Lee, Choon-Taek | - |
dc.contributor.author | Lee, Jae Ho | - |
dc.date.accessioned | 2024-08-08T01:36:01Z | - |
dc.date.available | 2024-08-08T01:36:01Z | - |
dc.date.created | 2018-08-31 | - |
dc.date.created | 2018-08-31 | - |
dc.date.issued | 2016-06 | - |
dc.identifier.citation | PLoS ONE, Vol.11 No.6, p. e0156917 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10371/206926 | - |
dc.description.abstract | Currently, there are two types of interferon-gamma release assays (IGRAs) in use for the detection of tuberculosis (TB) infection, the QuantiFERON-TB Gold In-Tube test (GFT-GIT) and T-SPOT.TB. Owing to contradictory reports regarding whether the results of these IGRAs are affected by the age of the patient, we aimed to determine if these two tests have age-related differences in sensitivity. We retrospectively reviewed the medical records of diagnosed TB patients who were tested using either QFT-GIT or T-SPOT.TB from February 2008 to December 2013. The positivity of the two tests was analyzed and compared with true TB infection, which was defined as active TB based on either a positive Mycobacterium culture or a positive TB polymerase chain reaction. The QFT-GIT group included 192 TB patients, and the T-SPOT.TB group included 212 TB patients. Of the patients with pulmonary TB, 76 (39.6%) were in the QFT-GIT group and 143 (67.5%) in the T-SPOT.TB group. The overall sensitivity was 80.2% for QFT-GIT and 91.0% for T.SPOT.TB. The sensitivities of QFT-GIT and T-SPOT.TB according to age group were as follows: <29 years, 93.3% and 96.7%; 30-49 years, 86.5% and 94.7%; 50-69 years, 76.8% and 87.5%; and >70 years, 68.3% and 85.7%, respectively. The trend of age-related changes in sensitivity was significant for both QFT-GIT (p = 0.004) and T.SPOT.TB (p = 0.039). However, only QFT-GIT was significantly related to age in the multivariate analysis. QFT-GIT, but not T-SPOT.TB, was significantly affected by patient age. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | Comparison of the sensitivity of QuantiFERON-TB Gold In-Tube and T-SPOT.TB according to patient age | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0156917 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000377369700153 | - |
dc.identifier.scopusid | 2-s2.0-84973477609 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | e0156917 | - |
dc.citation.volume | 11 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Kyoung Un | - |
dc.contributor.affiliatedAuthor | Song, Eun Young | - |
dc.contributor.affiliatedAuthor | Lee, Yeon Joo | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Il | - |
dc.contributor.affiliatedAuthor | Yim, Jae-Joon | - |
dc.contributor.affiliatedAuthor | Lee, Choon-Taek | - |
dc.contributor.affiliatedAuthor | Lee, Jae Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INTERFERON-GAMMA RELEASE | - |
dc.subject.keywordPlus | LATENT TUBERCULOSIS INFECTION | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | TB-2G TEST | - |
dc.subject.keywordPlus | IMMUNOCOMPROMISED PATIENTS | - |
dc.subject.keywordPlus | ACTIVE TUBERCULOSIS | - |
dc.subject.keywordPlus | HIGH PREVALENCE | - |
dc.subject.keywordPlus | SKIN-TEST | - |
dc.subject.keywordPlus | ASSAYS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
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