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Evaluation of Xpert® MTB/RIF assay: diagnosis and treatment outcomes in rifampicin-resistant tuberculosis : Evaluation of Xpert (R) MTB/RIF assay: diagnosis and treatment outcomes in rifampicin-resistant tuberculosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Y. W. | - |
dc.contributor.author | Seong, M. -W. | - |
dc.contributor.author | Kim, T. S. | - |
dc.contributor.author | Yoo, C. -G. | - |
dc.contributor.author | Kim, Y. W. | - |
dc.contributor.author | Han, S. K. | - |
dc.contributor.author | Yim, J. -J. | - |
dc.date.accessioned | 2024-08-08T01:38:29Z | - |
dc.date.available | 2024-08-08T01:38:29Z | - |
dc.date.created | 2018-11-06 | - |
dc.date.created | 2018-11-06 | - |
dc.date.issued | 2015-10 | - |
dc.identifier.citation | International Journal of Tuberculosis and Lung Disease, Vol.19 No.10, pp.1216-1221 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207104 | - |
dc.description.abstract | SETTING: The Xpert (R) MTB/RIF assay is endorsed by the World Health Organization for the detection of rifampicin (RMP) resistant tuberculosis (TB). OBJECTIVE: To evaluate Xpert for its diagnostic accuracy in detecting RMP-resistant TB and its impact on treatment outcomes. DESIGN: Patients with available phenotypic drug susceptibility testing (DST) results and those in whom RMP-resistant pulmonary TB was diagnosed using Xpert were evaluated. The accuracy and turnaround time (TAT) of Xpert for determining RMP-resistant TB was calculated. The TATs for treatment between patients diagnosed with RMP-resistant TB using Xpert and those diagnosed without the assay (phenotypic DST group) were compared. RESULTS: In 321 patients, when phenotypic DST was used as the gold standard, Xpert sensitivity and specificity for RMP resistance diagnosis was respectively 100% and 98.7%; the positive and negative predictive values were respectively 86.2% and 100%. The Xpert group had a much shorter interval from initial evaluation to commencing second-line anti-tuberculosis treatment (64 vs. 2 days, P < 0.001), and negative conversion of mycobacterial cultures (197 vs. 62.5 days, P < 0.001) than the phenotypic DST group. CONCLUSION: Xpert was accurate at diagnosing RMP resistance in this setting with an intermediate TB burden and a low level of RMP resistance. Xpert might reduce disease transmission by reducing the sputum culture conversion times for patients with RMP-resistant TB. | - |
dc.language | 영어 | - |
dc.publisher | International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories | - |
dc.title | Evaluation of Xpert® MTB/RIF assay: diagnosis and treatment outcomes in rifampicin-resistant tuberculosis | - |
dc.title.alternative | Evaluation of Xpert (R) MTB/RIF assay: diagnosis and treatment outcomes in rifampicin-resistant tuberculosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.5588/ijtld.15.0183 | - |
dc.citation.journaltitle | International Journal of Tuberculosis and Lung Disease | - |
dc.identifier.wosid | 000362154700016 | - |
dc.identifier.scopusid | 2-s2.0-84942756262 | - |
dc.citation.endpage | 1221 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 1216 | - |
dc.citation.volume | 19 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Y. W. | - |
dc.contributor.affiliatedAuthor | Seong, M. -W. | - |
dc.contributor.affiliatedAuthor | Yoo, C. -G. | - |
dc.contributor.affiliatedAuthor | Yim, J. -J. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | GENEXPERT MTB/RIF | - |
dc.subject.keywordPlus | RELIABILITY | - |
dc.subject.keywordPlus | AFRICA | - |
dc.subject.keywordAuthor | rapid molecular assay | - |
dc.subject.keywordAuthor | pulmonary tuberculosis | - |
dc.subject.keywordAuthor | MDR-TB | - |
dc.subject.keywordAuthor | turnaround time | - |
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