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Proteomic analysis of domestic pig pancreas during development using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Ji Ye | - |
dc.contributor.author | Kim, Il Yong | - |
dc.contributor.author | Oh, Sae Jin | - |
dc.contributor.author | Hwang, Hye Sook | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Kim, Yo Na | - |
dc.contributor.author | Shin, Jae Hoon | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.date.accessioned | 2024-08-08T01:41:57Z | - |
dc.date.available | 2024-08-08T01:41:57Z | - |
dc.date.created | 2020-12-09 | - |
dc.date.created | 2020-12-09 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | Laboratory Animal Research, Vol.30 No.2, pp.45-53 | - |
dc.identifier.issn | 1738-6055 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207413 | - |
dc.description.abstract | Pig pancreas may be a therapeutic resource for human diabetic patients. However, this potential ishindered by a lack of knowledge of the molecular events of pig pancreas development. In this study, theembryonic day 60, neonate and 6-month protein profiles of pig pancreas were ascertained at using twodimensionalgel electrophoresis and matrix assisted laser desorption/ionization-time of flight massspectrometry. Twenty four proteins were differentially expressed during pig pancreas development. Among them, 12 spots increased and 7 spots decreased according to development. The expression of 5protein were highest at birth. Expression of digestive enzymes including trypsin, pancreatic triacylglycerollipase and pancreatic alpha-amylase was elevated in adults, whereas chymotrypsins were highly expressedin neonates. Proteins that were abundantly expressed during gestation were alpha-1-antitrypsin, alphafetoproteinand transferrins. Taken together, we found out that several proteins were significantly up- ordown- regulated from pig pancreas based on developmental stage. This study will provide basis forunderstanding development of pig pancreas. | - |
dc.language | 영어 | - |
dc.publisher | 한국실험동물학회 | - |
dc.title | Proteomic analysis of domestic pig pancreas during development using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry | - |
dc.type | Article | - |
dc.identifier.doi | 10.5625/lar.2014.30.2.45 | - |
dc.citation.journaltitle | Laboratory Animal Research | - |
dc.citation.endpage | 53 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 45 | - |
dc.citation.volume | 30 | - |
dc.identifier.kciid | ART001890170 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yoon, Yeo Sung | - |
dc.contributor.affiliatedAuthor | Seong, Je Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | Domestic pig, pancreas, development, 2-DE proteomics, MALDI-TOF | - |
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