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The Effect of Cilostazol on Carotid Intima-Media Thickness Progression in Patients with Symptomatic Intracranial Atherosclerotic Stenosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Bum Joon | - |
dc.contributor.author | Rha, Joung-Ho | - |
dc.contributor.author | Kim, Seong Rae | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.contributor.author | Kim, Hahn Young | - |
dc.contributor.author | Lee, Ju-Hun | - |
dc.contributor.author | Bae, Hee Joon | - |
dc.contributor.author | Han, Moon Ku | - |
dc.contributor.author | Kang, Dong-Wha | - |
dc.contributor.author | Ratanakorn, Disya | - |
dc.contributor.author | Kim, Jong S. | - |
dc.contributor.author | Kwon, Sun U. | - |
dc.date.accessioned | 2024-08-08T01:42:06Z | - |
dc.date.available | 2024-08-08T01:42:06Z | - |
dc.date.created | 2021-01-19 | - |
dc.date.created | 2021-01-19 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.citation | Journal of Stroke and Cerebrovascular Diseases, Vol.23 No.5, pp.1164-1170 | - |
dc.identifier.issn | 1052-3057 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207433 | - |
dc.description.abstract | Background: The progression of carotid intima- media thickness (CIMT) is closely associated with ischemic stroke recurrence. However, the efficacy of cilostazol on preventing CIMT progression in stroke patients has never been investigated properly by a prospective trial. Methods: This study is a part of '' Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis- 2.'' Six centers that are available to measure CIMT according to the protocol participated in this substudy. After 7 months of randomization, the changes of CIMT were compared between cilostazol group and clopidogrel group. CIMT was measured by a semiautomated software (Intimascope) and was presented as the mean of maximum (CIMT- max) and average (CIMT- ave) of both common carotid arteries. Linear logistic regression analysis and analysis of covariance were performed to verify the independent factors associated with CIMT progression. Results: Among the 85 patients, 39 subjects were assigned to cilostazol group and 46 subjects to clopidogrel group. Follow- up CIMT significantly decreased in cilostazol group (CIMT-max: -.03 +/- .11 and CIMT-ave: -.02 +/- .08) compared with the increase in clopidogrel group (CIMT-max: .04 +/- .20 and CIMT-ave: .04 +/- .11; P = .05 and P = .04, respectively). Female, diabetes, and smoking were independently associated with the progression of CIMT, whereas the use of cilostazol was against CIMT progression from the results of linear regression analysis (P = .03 for both CIMT-max and CIMT-ave). The use of cilostazol also well predicted less progression of CIMT at follow-up after adjusting for baseline CIMT values and conventional risk factors (CIMT-max: P = .04 and CIMT-ave: P = .03). Conclusion: Cilostazol has a beneficial effect in preventing the progression of CIMT in ischemic stroke patients. | - |
dc.language | 영어 | - |
dc.publisher | W. B. Saunders Co., Ltd. | - |
dc.title | The Effect of Cilostazol on Carotid Intima-Media Thickness Progression in Patients with Symptomatic Intracranial Atherosclerotic Stenosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jstrokecerebrovasdis.2013.10.007 | - |
dc.citation.journaltitle | Journal of Stroke and Cerebrovascular Diseases | - |
dc.identifier.wosid | 000336482000068 | - |
dc.identifier.scopusid | 2-s2.0-84901368491 | - |
dc.citation.endpage | 1170 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1164 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bae, Hee Joon | - |
dc.contributor.affiliatedAuthor | Han, Moon Ku | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RANDOMIZED CONTROLLED-TRIALS | - |
dc.subject.keywordPlus | TYPE-2 DIABETES-MELLITUS | - |
dc.subject.keywordPlus | ARTERY INTIMA | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | COMMON | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | INFARCTION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordAuthor | Intracranial arterial stenosis | - |
dc.subject.keywordAuthor | intima | - |
dc.subject.keywordAuthor | media thickness | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordAuthor | antiplatelets | - |
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