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Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF-1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Hyun Kook | - |
dc.contributor.author | Kim, So Young | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Cheong, JaeHun | - |
dc.date.accessioned | 2024-08-08T01:42:37Z | - |
dc.date.available | 2024-08-08T01:42:37Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.citation | FEBS Letters, Vol.588 No.5, pp.733-739 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207480 | - |
dc.description.abstract | Hepatitis B virus X protein is a major factor in the HBV-induced disease developments. Stromal cell-derived factor-1 is a small cytokine that is strongly chemotactic for lymphocytes. We explored the role of HBx on recruitment of HBV-induced virus-nonspecific immune cells into liver. Immune cell recruitment and SDF-1 expression level significantly increased in livers of HBx-transgenic mice and X-box binding protein-1 significantly increased SDF-1 gene expression. Finally, we confirmed that immune cell recruitment into liver tissues of HBx-TG mice was diminished by a chemokine receptor antagonist. Therefore, HBx increases ER stress-dependent SDF-1 expression and induces HBVinduced immune cell recruitment into liver. (c) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF-1 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.febslet.2014.01.017 | - |
dc.citation.journaltitle | FEBS Letters | - |
dc.identifier.wosid | 000331717500014 | - |
dc.identifier.scopusid | 2-s2.0-84896706337 | - |
dc.citation.endpage | 739 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 733 | - |
dc.citation.volume | 588 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seong, Je Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | FACTOR-I | - |
dc.subject.keywordPlus | VIRAL CLEARANCE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IMMUNOPATHOGENESIS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordAuthor | ER stress | - |
dc.subject.keywordAuthor | HBx | - |
dc.subject.keywordAuthor | Immune cell recruitment | - |
dc.subject.keywordAuthor | SDF-1 | - |
dc.subject.keywordAuthor | XBP1 | - |
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