Publications
Detailed Information
Effect of treadmill exercise on interleukin-15 Expression and glucose tolerance in zucker diabetic fatty rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hee Jae | - |
dc.contributor.author | Park, Jae Young | - |
dc.contributor.author | Oh, Seung Lyul | - |
dc.contributor.author | Kim, Yong An | - |
dc.contributor.author | So, Byunghun | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Song, Wook | - |
dc.date.accessioned | 2024-08-08T01:43:11Z | - |
dc.date.available | 2024-08-08T01:43:11Z | - |
dc.date.created | 2022-05-12 | - |
dc.date.created | 2022-05-12 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.citation | Diabetes and Metabolism Journal, Vol.37 No.5, pp.358-364 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207556 | - |
dc.description.abstract | Background: Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose homeostasis and insulin sensitivity has been proposed. However, little is known regarding the influence of endurance training on IL-15 expression in type 2 diabetic skeletal muscles. We investigated the effect of endurance exercise training on glucose tolerance and IL-15 expression in skeletal muscles using type 2 diabetic animal models. Methods: Male Zucker diabetic fatty (ZDF) and ZDF lean control (ZLC) rats were randomly divided into three groups: sedentary ZLC, sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). The ZDF-Ex rats were forced to run a motor-driven treadmill for 60 minutes once a day 5 times per week for 12 weeks. Intraperitoneal glucose tolerance test (IPGTT) was performed after 12 weeks. Expression of IL-15 was measured using ELISA in extracted soleus (SOL) and gastrocnemius medial muscles. Results: After 12 weeks of treadmill training, reduction of body weight was observed in ZDF-Ex compared to ZDF-Con rats. Glucose tolerance using IPGTT in diabetic rats was significantly improved in ZDF-Ex rats. Furthermore, the expression of IL-15 was significantly increased (P<0.01) only in the SOL of ZDF-Ex rats compared to ZDF-Con. Additionally, IL-15 expression in SOL muscles was negatively correlated with change of body weight (R=-0.424, P=0.04). Conclusion: The present study results suggest that 12 weeks of progressive endurance training significantly improved glucose tolerance with concomitant increase of IL-15 expression in SOL muscles of type 2 diabetic rats. | - |
dc.language | 영어 | - |
dc.publisher | 대한당뇨병학회 | - |
dc.title | Effect of treadmill exercise on interleukin-15 Expression and glucose tolerance in zucker diabetic fatty rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.4093/dmj.2013.37.5.358 | - |
dc.citation.journaltitle | Diabetes and Metabolism Journal | - |
dc.identifier.scopusid | 2-s2.0-84887147523 | - |
dc.citation.endpage | 364 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 358 | - |
dc.citation.volume | 37 | - |
dc.identifier.kciid | ART001812544 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seong, Je Kyung | - |
dc.contributor.affiliatedAuthor | Song, Wook | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | interleukin 15 | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | endurance training | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gastrocnemius muscle | - |
dc.subject.keywordPlus | glucose tolerance | - |
dc.subject.keywordPlus | glucose tolerance test | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | non insulin dependent diabetes mellitus | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | sitting | - |
dc.subject.keywordPlus | skeletal muscle | - |
dc.subject.keywordPlus | soleus muscle | - |
dc.subject.keywordPlus | therapy effect | - |
dc.subject.keywordPlus | treadmill exercise | - |
dc.subject.keywordPlus | weight reduction | - |
dc.subject.keywordPlus | Zucker diabetic fatty rat | - |
dc.subject.keywordAuthor | Exercise | - |
dc.subject.keywordAuthor | Glucose intolerance | - |
dc.subject.keywordAuthor | Interleukin-15 | - |
dc.subject.keywordAuthor | Rats, Zucker | - |
dc.subject.keywordAuthor | Treadmill | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.