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Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | Lee, S. -H. | - |
dc.contributor.author | Park, H. -K. | - |
dc.contributor.author | Ryu, W. -S. | - |
dc.contributor.author | Lee, J. -S. | - |
dc.contributor.author | Bae, H. -J. | - |
dc.contributor.author | Han, M. -K. | - |
dc.contributor.author | Lee, Y. -S. | - |
dc.contributor.author | Kwon, H. -M. | - |
dc.contributor.author | Kim, C. K. | - |
dc.contributor.author | Park, E. -S. | - |
dc.contributor.author | Chung, J. -W. | - |
dc.contributor.author | Jung, K. -H. | - |
dc.contributor.author | Roh, J. -K. | - |
dc.date.accessioned | 2024-08-08T01:43:26Z | - |
dc.date.available | 2024-08-08T01:43:26Z | - |
dc.date.created | 2021-04-27 | - |
dc.date.created | 2021-04-27 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.citation | European Journal of Neurology, Vol.20 No.8, pp.1161-1169 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207601 | - |
dc.description.abstract | Background and purpose: We investigated the effect of celecoxib, a selective inhibitor of cyclo-oxygenase 2, in patients with intracerebral hemorrhage (ICH). Methods: We conducted a multicenter, randomized, controlled, and open with blinded end-point trial of 44 Korean patients 18 years or older with ICH within 24 h of onset. The intervention group (n = 20) received celecoxib (400 mg twice a day) for 14 days. The control group (n = 24) received the standard medical treatment for ICH. The primary end-point was the number of patients with a change in the volume of perihematomal edema (PHE) from the 1st to the 7th +/- 1 day (cut-off value, 20%). Results: The time from onset to computed tomography scan slightly differed between groups (177 +/- 160 min for control vs. 297 +/- 305 min for the celecoxib group; P = 0.10). In the primary end-point analysis using cut-off values, there was a significant shift to reduced expansion of PHE in the celecoxib group (P = 0.005). With respect to the secondary end-points, there was also a significant shift to reduced expansion of ICH in the celecoxib group (P = 0.046). In addition, the expansion rate of PHE at follow-up tended to be higher in the control group than in the celecoxib group (90.6 +/- 91.7% vs. 44.4 +/- 64.9%; P = 0.058). Conclusions: In our small, pilot trial, administration of celecoxib in the acute stage of ICH was associated with a smaller expansion of PHE than that observed in controls. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/ene.12140 | - |
dc.citation.journaltitle | European Journal of Neurology | - |
dc.identifier.wosid | 000321331100013 | - |
dc.identifier.scopusid | 2-s2.0-84880135647 | - |
dc.citation.endpage | 1169 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1161 | - |
dc.citation.volume | 20 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Bae, H. -J. | - |
dc.contributor.affiliatedAuthor | Han, M. -K. | - |
dc.contributor.affiliatedAuthor | Lee, Y. -S. | - |
dc.contributor.affiliatedAuthor | Kwon, H. -M. | - |
dc.contributor.affiliatedAuthor | Roh, J. -K. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVATED FACTOR-VII | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 INHIBITOR | - |
dc.subject.keywordPlus | NEOINTIMAL HYPERPLASIA | - |
dc.subject.keywordPlus | BRAIN EDEMA | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | ASPIRIN | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | brain edema | - |
dc.subject.keywordAuthor | celecoxib | - |
dc.subject.keywordAuthor | clinical trial | - |
dc.subject.keywordAuthor | intracerebral hemorrhage | - |
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