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Identification of the Effects of Aging-Related Gene-Matrix Metalloproteinase on Allograft Outcomes in Kidney Transplantation
DC Field | Value | Language |
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dc.contributor.author | Han, S. S. | - |
dc.contributor.author | Lee, H. | - |
dc.contributor.author | Oh, Y. J. | - |
dc.contributor.author | Lee, J. P. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Ha, J. | - |
dc.contributor.author | Kim, S. J. | - |
dc.contributor.author | Park, M. H. | - |
dc.contributor.author | Kim, Y. S. | - |
dc.contributor.author | Kim, D. K. | - |
dc.date.accessioned | 2024-08-08T01:43:30Z | - |
dc.date.available | 2024-08-08T01:43:30Z | - |
dc.date.created | 2021-04-26 | - |
dc.date.created | 2021-04-26 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | Transplantation Proceedings, Vol.45 No.6, pp.2158-2164 | - |
dc.identifier.issn | 0041-1345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207611 | - |
dc.description.abstract | Background. Aging plays a profound role in the ability of the kidney to function. Aging which varies among individuals, has been associated with the matrix metalloproteinase (MMP) 7 and 20 genes. This study was conducted to analyze correlations between polymorphisms of MMP genes [rs880197 in MMP7 (A>T) and rs1711437 in MMP20 (G>A)] and transplant outcomes in 235 recipients. Methods. Transplant outcomes were evaluated according to the sum of the A alleles in the recipients and the donors. The group with a high number of A alleles (>= 3) was compared with the group with a low number (<3). Results. The group with a high number of MMP7 A alleles showed a lower risk of chronic tubulointerstitial lesion than the group with a low number (P = .009). The group with a high number of MMP20 A alleles had showed better long-term kidney function at 10 years after transplantation than the group with a low number (P = .026). Furthermore, the group with a high number of MMP20 A alleles showed a trend toward better graft survival compared with the group with a low number, especially among recipients followed for >1 year (P = .022). Conclusions. Polymorphisms of MMP7 and MMP20 genes may be surrogate markers to predict long-term outcomes after kidney transplantation. | - |
dc.language | 영어 | - |
dc.publisher | Appleton & Lange | - |
dc.title | Identification of the Effects of Aging-Related Gene-Matrix Metalloproteinase on Allograft Outcomes in Kidney Transplantation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.transproceed.2013.03.020 | - |
dc.citation.journaltitle | Transplantation Proceedings | - |
dc.identifier.wosid | 000323852000015 | - |
dc.identifier.scopusid | 2-s2.0-84882284055 | - |
dc.citation.endpage | 2164 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 2158 | - |
dc.citation.volume | 45 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Ha, J. | - |
dc.contributor.affiliatedAuthor | Kim, D. K. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GLOMERULAR-FILTRATION-RATE | - |
dc.subject.keywordPlus | CELLULAR SENESCENCE | - |
dc.subject.keywordPlus | RENAL-TRANSPLANTATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | DISEASE | - |
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