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Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves
DC Field | Value | Language |
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dc.contributor.author | Sung, Mi-Ae | - |
dc.contributor.author | Jung, Hun Jong | - |
dc.contributor.author | Lee, Jung-Woo | - |
dc.contributor.author | Lee, Jin-Yong | - |
dc.contributor.author | Pang, Kang-Mi | - |
dc.contributor.author | Yoo, Sang Bae | - |
dc.contributor.author | Alrashdan, Mohammad S. | - |
dc.contributor.author | Kim, Soung-Min | - |
dc.contributor.author | Jahng, Jeong Won | - |
dc.contributor.author | Lee, Jong-Ho | - |
dc.date.accessioned | 2024-08-08T01:44:49Z | - |
dc.date.available | 2024-08-08T01:44:49Z | - |
dc.date.created | 2020-04-24 | - |
dc.date.created | 2020-04-24 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.citation | Neural Regeneration Research, Vol.7 No.26, pp.2018-2027 | - |
dc.identifier.issn | 1673-5374 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207784 | - |
dc.description.abstract | Several studies have demonstrated that human umbilical cord blood-derived mesenchymal stem cells can promote neural regeneration following brain injury. However, the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells in guiding peripheral nerve regeneration remain poorly understood. This study was designed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells on neural regeneration using a rat sciatic nerve crush injury model. Human umbilical cord blood-derived mesenchymal stem cells (1 x 10(6)) or a PBS control were injected into the crush-injured segment of the sciatic nerve. Four weeks after cell injection, brain-derived neurotrophic factor and tyrosine kinase receptor B mRNA expression at the lesion site was increased in comparison to control. Furthermore, sciatic function index, Fluoro Gold-labeled neuron counts and axon density were also significantly increased when compared with control. Our results indicate that human umbilical cord blood-derived mesenchymal stem cells promote the functional recovery of crush-injured sciatic nerves. | - |
dc.language | 영어 | - |
dc.publisher | Neural Regeneration Research | - |
dc.title | Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves | - |
dc.type | Article | - |
dc.identifier.doi | 10.3969/j.issn.1673-5374.2012.26.003 | - |
dc.citation.journaltitle | Neural Regeneration Research | - |
dc.identifier.wosid | 000309635800003 | - |
dc.identifier.scopusid | 2-s2.0-84888995213 | - |
dc.citation.endpage | 2027 | - |
dc.citation.number | 26 | - |
dc.citation.startpage | 2018 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Soung-Min | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Ho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ELECTRICAL-STIMULATION PROMOTES | - |
dc.subject.keywordPlus | PERIPHERAL-NERVE | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTORS | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | AXONAL REGENERATION | - |
dc.subject.keywordPlus | FUNCTIONAL RECOVERY | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordAuthor | human umbilical cord blood-derived mesenchymal stem cells | - |
dc.subject.keywordAuthor | sciatic nerve | - |
dc.subject.keywordAuthor | crush injury | - |
dc.subject.keywordAuthor | Fluoro Gold | - |
dc.subject.keywordAuthor | stem cells | - |
dc.subject.keywordAuthor | peripheral nerve regeneration | - |
dc.subject.keywordAuthor | regeneration | - |
dc.subject.keywordAuthor | neural regeneration | - |
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