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Expansion of Tfh-like cells during chronic Salmonella exposure mediates the generation of autoimmune hypergammaglobulinemia in MyD88-deficient mice
DC Field | Value | Language |
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dc.contributor.author | Ko, Hyun-Jeong | - |
dc.contributor.author | Yang, Hyungjun | - |
dc.contributor.author | Yang, Jin-Young | - |
dc.contributor.author | Seo, Sang-Uk | - |
dc.contributor.author | Chang, Sun-Young | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Kweon, Mi-Na | - |
dc.date.accessioned | 2024-08-08T01:45:24Z | - |
dc.date.available | 2024-08-08T01:45:24Z | - |
dc.date.created | 2020-11-12 | - |
dc.date.created | 2020-11-12 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | European Journal of Immunology, Vol.42 No.3, pp.618-628 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | https://hdl.handle.net/10371/207874 | - |
dc.description.abstract | The role of TLR signaling in linking the innate and adaptive immune systems has been a controversial issue that remains to be solved. Here, we determined whether MyD88-dependent TLR signals are required for the generation of B-cell responses during chronic Salmonella infection. Oral administration of recombinant attenuated Salmonella enterica serovar Typhimurium vaccine (RASV) strain in MyD88-/- mice resulted in chronic infection. Infection was accompanied by enlarged germinal centers and hypergammaglobulinemia with anti-double-stranded DNA (dsDNA)-specific Ab in sera, and the deposition of immune complexes in the kidneys, suggesting onset of autoimmunity. CD4+ T cells expressing PD-1, CXCR5, ICOS, and IL-21 were dramatically increased in chronically infected mice, indicating the expansion of follicular helper T (Tfh)-like cells. Of note, the depletion of CD4+ T cells completely blocked the generation of polyclonal IgG Ab in sera after oral RASV challenge. Inflammatory myeloid cells expressing CD11b and Gr-1 accumulated in high numbers in the spleen of MyD88-/- mice. Interestingly, the blockade of PD-1 or ICOS significantly reduced the hypergammaglobulinemia and dsDNA-specific autoantibody production. Overall, these results suggest that Tfh-like cells in chronic bacterial infection trigger autoimmune hypergammaglobulinemia in a PD-1- and ICOS-dependent manner. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Expansion of Tfh-like cells during chronic Salmonella exposure mediates the generation of autoimmune hypergammaglobulinemia in MyD88-deficient mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/eji.201141748 | - |
dc.citation.journaltitle | European Journal of Immunology | - |
dc.identifier.wosid | 000302541300010 | - |
dc.identifier.scopusid | 2-s2.0-84859515417 | - |
dc.citation.endpage | 628 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 618 | - |
dc.citation.volume | 42 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Seong, Je Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FOLLICULAR-HELPER-CELLS | - |
dc.subject.keywordPlus | GERMINAL CENTER RESPONSES | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | BACTERIAL-INFECTION | - |
dc.subject.keywordPlus | HUMORAL IMMUNITY | - |
dc.subject.keywordPlus | ORAL VACCINATION | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | PLASMA-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordAuthor | Autoimmune disease | - |
dc.subject.keywordAuthor | Follicular helper T cells | - |
dc.subject.keywordAuthor | Hypergammaglobulinemia | - |
dc.subject.keywordAuthor | MyD88 | - |
dc.subject.keywordAuthor | Salmonella | - |
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