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Donepezil treatment in Alzheimer's disease patients with and without cerebrovascular lesions: A preliminary report
Cited 7 time in
Web of Science
Cited 7 time in Scopus
- Authors
- Issue Date
- 2011-01
- Publisher
- Wiley-Blackwell
- Citation
- Geriatrics & Gerontology International, Vol.11 No.1, pp.90-97
- Abstract
- Aim: Donepezil has not been evaluated in Korean patients with Alzheimer's disease (AD) for up to 1 year. The objectives of this study were to evaluate the differential efficacy of donepezil in Korean AD patients with and without concomitant cerebrovascular lesions (CVL). Methods: This study was a 48-week open-label trial of donepezil in patients with probable AD of mild to moderate severity. CVL were evaluated through magnetic resonance imaging (MRI) findings within 3 months. Efficacy analyses were performed for cognitive, behavioral and functional outcome measures. Results: Concomitant CVL were documented in 35 (30.7%) of the patients on MRI. Seventy-nine (69.3%) of the patients were considered not to have concomitant CVL. The mean Mini-Mental State Examination scores of both patients with and without CVL showed improvement at each evaluation. However, there was no statistical difference in improvement between the groups. Conclusion: The presence of CVL should not deter clinicians from treating AD with donepezil. Geriatr Gerontol Int 2011; 11: 90-97.
- ISSN
- 1444-1586
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